4.7 Article

Association between urate-lowering therapies and cognitive decline in community-dwelling older adults

Journal

SCIENTIFIC REPORTS
Volume 12, Issue 1, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41598-022-17808-6

Keywords

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Funding

  1. French Ministry of Health
  2. University Hospital Center of Toulouse/Gerontopole
  3. Pierre Fabre Research Institute
  4. ExonHit Therapeutics
  5. University Hospital Center of Toulouse
  6. Association Monegasque pour la Recherche sur la maladie d'Alzheimer (AMPA)
  7. Region Occitanie/Pyrenees-Mediterranee [1901175]
  8. European Regional Development Fund (ERDF) [MP0022856]
  9. Alzheimer Prevention in Occitania and Catalonia (APOC Chair of Excellence-Inspire Program)
  10. Avid Radiopharmaceuticals
  11. UMR 1027 Unit INSERM-University of Toulouse III

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This article examined the association between long-term use of urate-lowering therapies (ULT) and cognitive decline among community-dwelling older adults and found that ULT use was not associated with reduced cognitive decline over a 5-year follow-up. The study provides important insights into the relationship between cognitive function and urate-lowering therapies.
Long-term use of urate-lowering therapies (ULT) may reduce inflammaging and thus prevent cognitive decline during aging. This article examined the association between long-term use of ULT and cognitive decline among community-dwelling older adults with spontaneous memory complaints. We performed a secondary observational analysis using data of 1673 participants >= 70 years old from the Multidomain Alzheimer Preventive Trial (MAPT Study), a randomized controlled trial assessing the effect of a multidomain intervention, the administration of polyunsaturated fatty acids (PUFA), both, or placebo on cognitive decline. We compared cognitive decline during the 5-year follow-up between three groups according to ULT (i.e. allopurinol and febuxostat) use: participants treated with ULT during at least 75% of the study period (PT >= 75; n = 51), less than 75% (PT < 75; n = 31), and non-treated participants (PNT; n = 1591). Cognitive function (measured by a composite score) was assessed at baseline, 6 months and every year for 5 years. Linear mixed models were performed and results were adjusted for age, sex, body mass index (BMI), diagnosis of arterial hypertension or diabetes, baseline composite cognitive score, and MAPT intervention groups. After the 5-year follow-up, only non-treated participants presented a significant decline in the cognitive composite score (mean change - 0.173, 95%CI - 0.212 to - 0.135; p < 0.0001). However, there were no differences in change of the composite cognitive score between groups (adjusted between-group difference for PT >= 75 vs. PNT: 0.144, 95%CI - 0.075 to 0.363, p = 0.196; PT < 75 vs. PNT: 0.103, 95%CI - 0.148 to 0.353, p = 0.421). Use of ULT was not associated with reduced cognitive decline over a 5-year follow-up among community-dwelling older adults at risk of dementia.

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