Journal
NUTRIENTS
Volume 14, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/nu14204260
Keywords
salt; gastric cancer; case-control study; meta-analysis; prevention
Categories
Funding
- National Natural Science Foundation of China [82273676]
- National Key Research and Development Program of China [2021YFA1301200, 2021YFA1301202]
- Liaoning province scientific and technological project [2021JH2/10300039]
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A meta-analysis showed a significant positive association between high dietary salt intake and gastric cancer risk. These findings have implications for the prevention of gastric cancer.
Aim: The effect of dietary salt intake on the risk of gastric cancer is not clear. A meta-analysis was performed to estimate the association between dietary salt intake and the risk of gastric cancer. Methods: Three major databases were searched to retrieve case-control studies published in English before 1 July 2022. Random effects model analysis was used to obtain the pooled odds ratios (ORs) and 95% confidence intervals (CIs) of the association between dietary salt intake and risk of gastric cancer. Subgroup analyses were used to identify possible sources of heterogeneity. Results: Thirty-eight case-control studies were included in this meta-analysis (total population: n = 37,225). The pooled ORs showed a significantly positive association between high salt intake and gastric cancer compared with low salt intake (OR = 1.55, 95% CI (1.45, 1.64); p < 0.001). In subgroup meta-analysis for geographic region, estimation method for dietary salt intake and the source of controls, this association was not changed. Conclusion: Higher dietary salt intake increased the risk of gastric cancer. This study has implications for the prevention of gastric cancer.
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