4.7 Review

The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia-A Narrative Review

Related references

Note: Only part of the references are listed.
Article Nutrition & Dietetics

Baseline iron and low-grade inflammation modulate the effectiveness of iron supplementation: evidence from follow-up of pregnant Sri Lankan women

Miruna Sudharshani Kalaimani Rabindrakumar et al.

Summary: Iron supplementation during pregnancy is influenced by baseline iron levels and inflammatory status, particularly in women with high BMI and excessive weight gain.

EUROPEAN JOURNAL OF NUTRITION (2021)

Review Nutrition & Dietetics

Iron deficiency, immunology, and colorectal cancer

Oliver Phipps et al.

Summary: Iron levels play a crucial role in the pathogenesis of colorectal cancer, with both excessive and insufficient iron intake being associated with negative outcomes on cancer immunosurveillance and treatment response.

NUTRITION REVIEWS (2021)

Review Medicine, General & Internal

Iron deficiency

Sant-Rayn Pasricha et al.

Summary: Iron deficiency is a major contributor to the global burden of disease, particularly affecting children, premenopausal women, and those in low-income and middle-income countries. Oral iron therapy is usually the first line of treatment, but high-dose oral iron supplementation and iron absorption during inflammation may be limited by hepcidin upregulation.

LANCET (2021)

Review Nutrition & Dietetics

Iron Deficiency Anemia in Inflammatory Bowel Diseases-A Narrative Review

Dagmara Mahadea et al.

Summary: Inflammatory bowel disease (IBD) often causes iron deficiency anemia, which significantly impacts quality of life and presents with various symptoms. Treatment should follow guidelines for monitoring anemia, considering appropriate therapy and the type of iron supplementation.

NUTRIENTS (2021)

Article Oncology

Anticancer effects of bifidobacteria on colon cancer cell lines

Zeinab Faghfoori et al.

Summary: The study showed that different species of bifidobacteria exhibit anticancer activity on colorectal cancer cells by regulating the expression of anti-apoptotic and pro-apoptotic genes, potentially contributing to the prevention and treatment of colorectal cancer. Further research is needed to fully understand the mechanisms behind apoptosis induction by bifidobacteria species.

CANCER CELL INTERNATIONAL (2021)

Review Cell Biology

High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review

Ida Judyta Malesza et al.

Summary: The gut microbiota plays a crucial role in extracting energy from food, providing vitamins to the host, and acting as a barrier against exogenous pathogens. The Western diet, characterized by overeating, frequent snacking, and prolonged postprandial state, has been associated with dysbiosis and inflammation linked to excessive fat consumption.

CELLS (2021)

Review Nutrition & Dietetics

The Effect of Perioperative Administration of Probiotics on Colorectal Cancer Surgery Outcomes

Louise Pitsillides et al.

Summary: Probiotics may help lower the rates of infectious and non-infectious complications, reduce bacterial translocation, maintain intestinal mucosal permeability, and provide a better balance of beneficial to pathogenic microorganisms in CRC patients during the perioperative period.

NUTRIENTS (2021)

Article Biochemistry & Molecular Biology

Dietary Iron Intake in Excess of Requirements Impairs Intestinal Copper Absorption in Sprague Dawley Rat Dams, Causing Copper Deficiency in Suckling Pups

Jennifer K. Lee et al.

Summary: Physiologically relevant iron-copper interactions have been frequently documented, with excess enteral iron inhibiting copper absorption and leading to copper depletion in pregnant and lactating dams and their pups. This highlights the importance of considering the impact of excess iron supplementation on copper absorption and homeostasis.

BIOMEDICINES (2021)

Review Medicine, Research & Experimental

Association between obesity and iron deficiency (Review)

Naseem Mohammad Alshwaiyat et al.

Summary: Obesity is associated with iron deficiency anemia, possibly due to disruptions in iron homeostasis and increased hepcidin levels mediated by chronic inflammation. Significant weight loss in overweight and obese individuals may improve iron status by reducing inflammation and increasing iron absorption, but additional randomized controlled trials are needed to confirm this effect.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Review Gastroenterology & Hepatology

Iron homeostasis in host and gut bacteria - a complex interrelationship

Yohannes Seyoum et al.

Summary: Iron deficiency is a common nutritional issue affecting 1.4 billion people worldwide. The usual approach to combating it, iron fortification, can have undesired side effects and may not always be effective. This review aims to explore the complex relationship between iron and gut microbiota, potentially offering more efficient ways to address anemia caused by iron deficiency.

GUT MICROBES (2021)

Review Food Science & Technology

Mechanism and intervention measures of iron side effects on the intestine

Xiao Qi et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Review Nutrition & Dietetics

Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review

Michael W. Rohr et al.

ADVANCES IN NUTRITION (2020)

Article Cell Biology

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

Nupur K. Das et al.

CELL METABOLISM (2020)

Review Medicine, General & Internal

Iron deficiency anaemia revisited

M. D. Cappellini et al.

JOURNAL OF INTERNAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

Mechanism of colorectal carcinogenesis triggered by heme iron from red meat

Nina Seiwert et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Article Gastroenterology & Hepatology

Use of intravenous iron therapy in colorectal cancer patient with iron deficiency anemia: a propensity-score matched study

Philip Ming-Ho Kam et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2020)

Review Biochemistry & Molecular Biology

Inflammatory bowel disease: between genetics and microbiota

Nour Younis et al.

MOLECULAR BIOLOGY REPORTS (2020)

Review Medicine, General & Internal

Oral Iron for IBD Patients: Lessons Learned at Time of COVID-19 Pandemic

Ferdinando D'Amico et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Immunology

The battle for iron in enteric infections

Ana Sousa Geros et al.

IMMUNOLOGY (2020)

Review Medicine, Research & Experimental

Overdosing on iron: Elevated iron and degenerative brain disorders

Santosh R. D'Mello et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Article Pediatrics

Relationship between Obesity and Iron Deficiency in Healthy Adolescents

Maria Ortiz Perez et al.

CHILDHOOD OBESITY (2020)

Article Oncology

Analyses of Potential Driver and Passenger Bacteria in Human Colorectal Cancer

Yijia Wang et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Review Agriculture, Dairy & Animal Science

Regulation of the intestinal barrier by nutrients: The role of tight junctions

Takuya Suzuki

ANIMAL SCIENCE JOURNAL (2020)

Article Gastroenterology & Hepatology

Efficacy of iron supplementation in patients with inflammatory bowel disease treated with anti-tumor necrosis factor-alpha agents

Su Young Kim et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2020)

Article Oncology

Metabolic models predict bacterial passengers in colorectal cancer

Daniel R. Garza et al.

CANCER & METABOLISM (2020)

Review Immunology

Heme Uptake and Utilization by Gram-Negative Bacterial Pathogens

Kaylie L. Richard et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Review Biochemistry & Molecular Biology

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

Toshitaka Nakamura et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

Review Biochemistry & Molecular Biology

Iron homeostasis and oxidative stress: An intimate relationship

Dimitrios Galaris et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Medicine, Research & Experimental

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

Andrew J. Schwartz et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Gastroenterology & Hepatology

Obesity, diabetes, and the gut microbiome: an updated review

Tahli Singer-Englar et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Agriculture, Dairy & Animal Science

Effects of oxidative stress induced by high dosage of dietary iron ingested on intestinal damage and caecal microbiota in Chinese Yellow broilers

Z. Y. Gou et al.

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION (2018)

Review Nutrition & Dietetics

Rational Management of Iron-Deficiency Anaemia in Inflammatory Bowel Disease

Ole Haagen Nielsen et al.

NUTRIENTS (2018)

Review Food Science & Technology

Colibactin: More Than a New Bacterial Toxin

Tiphanie Fais et al.

TOXINS (2018)

Article Multidisciplinary Sciences

Oral iron exacerbates colitis and influences the intestinal microbiome

Awad Mahalhal et al.

PLOS ONE (2018)

Review Gastroenterology & Hepatology

Practical guidance for the management of iron deficiency in patients with inflammatory bowel disease

Dorothea Niepel et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2018)

Review Gastroenterology & Hepatology

Intestinal microbiota, chronic inflammation, and colorectal cancer

Chan Hyuk Park et al.

INTESTINAL RESEARCH (2018)

Review Gastroenterology & Hepatology

Impact of microbiota in colorectal carcinogenesis: lessons from experimental models

Linda Chia-Hui Yu et al.

INTESTINAL RESEARCH (2018)

Review Chemistry, Medicinal

Gut Microbiota and Iron: The Crucial Actors in Health and Disease

Bahtiyar Yilmaz et al.

PHARMACEUTICALS (2018)

Review Medicine, General & Internal

Dysmetabolic iron overload syndrome (DIOS)

Yves Deugnier et al.

PRESSE MEDICALE (2017)

Article Microbiology

Dynamics of the human gut microbiome in inflammatory bowel disease

Jonas Halfvarson et al.

NATURE MICROBIOLOGY (2017)

Article Nutrition & Dietetics

The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: a review

Daniela Paganini et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

Article Nutrition & Dietetics

Current understanding of iron homeostasis

Gregory J. Anderson et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

Article Gastroenterology & Hepatology

Consumption of a high-iron diet disrupts homeostatic regulation of intestinal copper absorption in adolescent mice

Jung-Heun Ha et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)

Article Biochemistry & Molecular Biology

Lipid peroxidation in cell death

Michael M. Gaschler et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Gastroenterology & Hepatology

Geographical patterns of the standing and active human gut microbiome in health and IBD

Ateequr Rehman et al.

Article Biochemistry & Molecular Biology

Iron uptake and transport across physiological barriers

Kari A. Duck et al.

BIOMETALS (2016)

Article Medicine, Research & Experimental

Effects of iron supplementation in mice with hypoferremia induced by obesity

Erica Martins Ferreira Gotardo et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Review Medicine, General & Internal

Iron deficiency anaemia

Anthony Lopez et al.

LANCET (2016)

Review Gastroenterology & Hepatology

Iron and the liver

Antonello Pietrangelo

LIVER INTERNATIONAL (2016)

Article Agriculture, Dairy & Animal Science

Regeneration of the intestinal mucosa in Eimeria and E. Coli challenged broilers supplemented with amino acids

E. T. Gottardo et al.

POULTRY SCIENCE (2016)

Article Gastroenterology & Hepatology

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese

Ali Shawki et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2015)

Article Microbiology

Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection

Manfred Nairz et al.

CELL HOST & MICROBE (2015)

Article Biochemistry & Molecular Biology

Body mass index, iron absorption and iron status in childbearing age women

Maria Fernanda Mujica-Coopman et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2015)

Review Medicine, General & Internal

Changes seen in gut bacteria content and distribution with obesity: causation or association?

David S. H. Bell

POSTGRADUATE MEDICINE (2015)

Article Multidisciplinary Sciences

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

Noortje Ijssennagger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Nutrition & Dietetics

Obesity Promotes Alterations in Iron Recycling

Marta Citelli et al.

NUTRIENTS (2015)

Review Nutrition & Dietetics

Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation

Darius J. R. Lane et al.

NUTRIENTS (2015)

Review Psychiatry

Childhood maltreatment and inflammatory markers: a systematic review

R. Coelho et al.

ACTA PSYCHIATRICA SCANDINAVICA (2014)

Review Gastroenterology & Hepatology

Mechanistic and regulatory aspects of intestinal iron absorption

Sukru Gulec et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)

Review Pharmacology & Pharmacy

Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

Aleksandra Piechota-Polanczyk et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2014)

Article Gastroenterology & Hepatology

Inflammation and colorectal cancer, when microbiota-host mutualism breaks

Marco Candela et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Nutrition & Dietetics

Obesity as an Emerging Risk Factor for Iron Deficiency

Elmar Aigner et al.

NUTRIENTS (2014)

Review Pharmacology & Pharmacy

The IRP/IRE system in vivo: insights from mouse models

Nicole Wilkinson et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Biochemistry & Molecular Biology

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

Marcelo Farina et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

Article Microbiology

Co-occurrence of anaerobic bacteria in colorectal carcinomas

Rene L. Warren et al.

MICROBIOME (2013)

Article Biochemistry & Molecular Biology

High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption

Thomas Sonnweber et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Intestinal iron absorption

Brie K. Fuqua et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2012)

Review Microbiology

A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects

Harold Tjalsma et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Review Medicine, General & Internal

Iron Overload in Human Disease

Robert E. Fleming et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Multidisciplinary Sciences

Hepcidin and the Iron-Infection Axis

Hal Drakesmith et al.

SCIENCE (2012)

Review Biochemistry & Molecular Biology

Non Transferrin Bound Iron: Nature, Manifestations and Analytical Approaches for Estimation

Meghna Patel et al.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2012)

Review Hematology

Hepcidin and iron regulation, 10 years later

Tomas Ganz

BLOOD (2011)

Article Endocrinology & Metabolism

Hemojuvelin: A New Link Between Obesity and Iron Homeostasis

Nathalie Luciani et al.

OBESITY (2011)

Review Pharmacology & Pharmacy

Advances in metal-induced oxidative stress and human disease

Klaudia Jomova et al.

TOXICOLOGY (2011)

Review Medicine, General & Internal

Optimal management of iron deficiency anemia due to poor dietary intake

Kattalin Aspuru et al.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2011)

Article Nutrition & Dietetics

The effects of iron fortification on the gut microbiota in African children a randomized controlled trial in Cote d'Ivoire

Michael B. Zimmermann et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

Article Nutrition & Dietetics

Iron bioavailability and dietary reference values

Richard Hurrell et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

Article Public, Environmental & Occupational Health

A new classification of foods based on the extent and purpose of their processing

Carlos Augusto Monteiro et al.

CADERNOS DE SAUDE PUBLICA (2010)

Review Nutrition & Dietetics

Metabolic crossroads of iron and copper

James F. Collins et al.

NUTRITION REVIEWS (2010)

Article Biochemistry & Molecular Biology

The role of Dcytb in iron metabolism: an update

Andrew T. McKie

BIOCHEMICAL SOCIETY TRANSACTIONS (2008)

Article Medical Laboratory Technology

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

Dimitrios Galaris et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2008)

Editorial Material Gastroenterology & Hepatology

Mechanisms of heme iron absorption: Current questions and controversies

Adrian R. West et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

Exacerbation of dextran sulfate sodium-induced colitis by dietary iron supplementation:: role of NF-κB

JC Carrier et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2006)

Article Oncology

Evidence that hydrogen sulfide is a genotoxic agent

MS Attene-Ramos et al.

MOLECULAR CANCER RESEARCH (2006)

Article Gastroenterology & Hepatology

Iron Imports. II. Iron uptake at the apical membrane in the intestine

B Mackenzie et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)

Review Medicine, General & Internal

Medical progress: Anemia of chronic disease

G Weiss et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)