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Gastrointestinal Microbiome and Multiple Health Outcomes: Umbrella Review

Journal

NUTRIENTS
Volume 14, Issue 18, Pages -

Publisher

MDPI
DOI: 10.3390/nu14183726

Keywords

gastrointestinal microbiome; gut microbiota; gut flora; probiotics; prebiotic; synbiotics; health; meta analysis; systematic reviews

Funding

  1. key research and development project of Science & Technology Department of Sichuan Province [2021YFS0022]

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The gastrointestinal microbiome is associated with various health outcomes, and current interventions are generally safe and beneficial. However, the quality of evidence is not high, and more randomized controlled trials are needed.
In recent years, there has been growing concern about the impact of the gastrointestinal microbiome on human health outcomes. To clarify the evidence for a link between the gastrointestinal microbiome and a variety of health outcomes in humans, we conducted an all-encompassing review of meta-analyses and systematic reviews that included 195 meta-analyses containing 950 unique health outcomes. The gastrointestinal microbiome is related to mortality, gastrointestinal disease, immune and metabolic outcomes, neurological and psychiatric outcomes, maternal and infant outcomes, and other outcomes. Existing interventions for intestinal microbiota (such as probiotics, fecal microbiota transplant, etc.) are generally safe and beneficial to a variety of human health outcomes, but the quality of evidence is not high, and more detailed and well-designed randomized controlled trials are necessary.

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