Journal
NUTRIENTS
Volume 14, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/nu14214577
Keywords
type 2 diabetes mellitus; chronic inflammation; biomarkers of inflammation; dietary patterns; Mediterranean Diet
Categories
Funding
- Universidad Autonoma del Estado de Mexico/CONACYT
- Universidad Autonoma del Estado de Mexico
Ask authors/readers for more resources
The presence of chronic low-grade inflammation is associated with the development of type 2 diabetes mellitus, and certain dietary patterns have been found to have favorable effects on inflammatory biomarkers. This systematic review and meta-analysis indicates that adherence to healthy dietary patterns is associated with reduced levels of C-reactive protein and increased levels of adiponectin, suggesting a reduction in inflammation.
Some evidence supports the fact that chronic low-grade inflammation contributes to the physiopathology of type 2 diabetes mellitus (T2DM), and circulating markers of inflammation (e.g., C-reactive protein (CRP), pro- and anti-inflammatory biomarkers (e.g., adiponectin), and endothelial function markers could indicate an ongoing pathology. Following certain dietary patterns (DPs) may result in favorable changes in inflammatory biomarkers. The overarching aim of this systematic review and meta-analysis is to explore the inflammatory effect of healthy DPs on inflammatory biomarkers in adults with T2DM. A systematic search of the literature was conducted using the electronic databases MEDLINE, SCOPUS, and Cochrane Central Register of Controlled Trials. A total of 10 randomized controlled clinical trials (RCTs) were analyzed. In our linear meta-analysis, the random-effects model was applied to estimate standardized mean differences (SMD) to associate the effect of the interventions. Dietary Approaches to Stop Hypertension (DASH), Diabetes UK healthy eating, Mediterranean Diet (MD), Diabetes Prevention Program (DPP), and the American Heart Association's Therapeutic Lifestyle Changes diet were associated with a significant reduction in CRP (SMD: -0.83, 99% CI -1.49, -0.17, p < 0.001; I-2 94%), while plasma levels of adiponectin were significantly higher with the intake of MD, DPP, and Diabetes UK healthy eating (SMD: 0.81, 99% CI 0.06,1.56, p < 0.005; I-2 96%), both of which indicate less inflammation. Sensitivity analyses were carried out, and potential publication bias was examined. In conclusion, low- moderate-quality evidence from RCTs suggests that, for the DPs evaluated, there are favorable changes in CRP and adiponectin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available