☆ 4.7 Review

Efficacy of Flavonoids on Animal Models of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

NUTRIENTS (2022)

Related references

Note: Only part of the references are listed.

Review Food Science & Technology

Efficacy of flavonoids on biomarkers of type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

Fanling Liu et al.

Summary: A systematic review and meta-analysis of 28 randomized controlled trials found that flavonoid intake can significantly reduce fasting blood glucose, hemoglobin A1c, and other biomarkers related to Type 2 diabetes mellitus. Flavonoid intake has modest but statistically significant benefits in glucose metabolism, insulin sensitivity, and lipid metabolism.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Add to Collection

Article Medicine, General & Internal

Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis

Fangxin Peng et al.

Summary: The study demonstrates that Apigenin can improve hormone levels, lipid metabolism, and antioxidant status in PCOS rats.

ANNALS OF MEDICINE (2022)

Add to Collection

Article Obstetrics & Gynecology

Emulating a target trial of the comparative effectiveness of clomiphene citrate and letrozole for ovulation induction

Jennifer J. Yland et al.

Summary: For women with PCOS, letrozole was associated with higher risks of pregnancy, livebirth, and neonatal outcomes compared to clomiphene. In women with unexplained infertility, the two treatments resulted in comparable outcomes.

HUMAN REPRODUCTION (2022)

Add to Collection

Article Plant Sciences

Crocus sativus (saffron) petals extract and its active ingredient, anthocyanin improves ovarian dysfunction, regulation of inflammatory genes and antioxidant factors in testosterone-induced PCOS mice

Fazeleh Moshfegh et al.

Summary: This study examined the effects of saffron petal extract (SPE) and saffron petal anthocyanins (SPA) on ovarian hormones, steroidogenic enzymes, ovarian dysfunction, regulation of anti-inflammatory genes, and antioxidant factors in female PCOS mice. The results suggest that SPE and SPA can improve dysregulation of ovarian steroids, steroidogenic enzymes, antioxidant enzymes and inflammatory markers in PCOS mice, ameliorating symptoms of PCOS.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome

Asmaa A. Mahmoud et al.

Summary: The study demonstrated that quercetin and metformin both show anti-androgenic effects in a DHEA-induced PCOS rat model, reducing hyperandrogenism and improving ovarian function. Both treatments increase estradiol levels, decrease atretic follicles, and prevent cyst formation in PCOS rats. In addition, quercetin and metformin can enhance folliculogenesis and reduce atresia through attenuation of hyperandrogenism.

STEROIDS (2022)

Add to Collection

Article Medicine, General & Internal

Original Article Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats

Shaoyan Zheng et al.

Summary: The study found that quercetin could regulate the expression of CNP/NPR2 genes and proteins by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, thereby restoring the maturation of oocyte and ovulation in the PCOS rat model, and alleviating the hormone, metabolic, and ovulatory aberrations caused by PCOS.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2022)

Add to Collection

Review Pharmacology & Pharmacy

Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis

Anzhu Wang et al.

Summary: This study aimed to investigate the effects and underlying mechanisms of paeoniflorin (PF) on cerebral ischemia-reperfusion (I/R) injury. Meta-analysis results showed that compared to the control group, PF significantly reduced neurological severity scores, cerebral infarction size, brain water content, apoptosis cells, and levels of inflammatory factors. Therefore, PF may be a promising therapeutic for managing cerebral I/R injury.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Bio-enhancement of Soy Isoflavones (Genistein & Daidzein) Using Bacillus coagulans in Letrozole Induced Polycystic Ovarian Syndrome by Regulating Endocrine Hormones in Rats

Jeshica Bulsara et al.

Summary: This study investigated the enhancement of bioactivity of soy isoflavones (SIF) by Bacillus coagulans (B. coagulans). Animal experiments showed that the combination of SIF and B. coagulans restored hormone balance, reduced oxidative stress, improved the menstrual cycle, and enhanced ovarian physiology. The study also revealed that a higher dose of B. coagulans was more effective in alleviating symptoms of polycystic ovarian syndrome (PCOS).

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2022)

Add to Collection

Article Chemistry, Applied

Butylated starch alleviates polycystic ovary syndrome by stimulating the secretion of peptide tyrosine-tyrosine and regulating faecal microbiota

Yufeng He et al.

Summary: Butylated starch treatment can alleviate abnormal ovarian morphology, metabolic disorders, and sex hormone imbalance in PCOS. This effect may be mediated by the activation of GPR41 and the enrichment of butyrate-producing microbes in fecal microbiota.

CARBOHYDRATE POLYMERS (2022)

Add to Collection

Review Food Science & Technology

Anti-obesity properties and mechanism of action of flavonoids: A review

Anne Karoline de Souza Oliveira et al.

Summary: Flavonoids, a group of natural substances, have shown promising anti-obesity effects by modulating various biological activities that decrease lipogenesis, increase lipolysis, expend energy, stimulate fatty acids B-oxidation, as well as digestion and metabolism of carbohydrates. Additionally, flavonoids can mitigate inflammatory responses and suppress oxidative stress, making them potential compounds for treating obesity and its associated comorbidities.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Recent Research on Flavonoids and their Biomedical Applications

Kangmei Wen et al.

Summary: Flavonoids, a class of polyphenolic compounds with a basic structural unit of 2-phenylchromone, have wide potential applications in biomedicine. A review of literature on the medical use of flavonoids in the past decade has documented their pharmacological activities and mechanisms of action against various health disorders. The findings provide suggestions for further research on the biomedical applications of flavonoids.

CURRENT MEDICINAL CHEMISTRY (2021)

Add to Collection

Review Nutrition & Dietetics

Polyphenols and Human Health: The Role of Bioavailability

Chiara Di Lorenzo et al.

Summary: Polyphenols are a group of phytochemicals with potential health-promoting effects, classified as flavonoid and non-flavonoid molecules. Their positive effects on health are influenced by factors affecting their bioavailability, and recent studies have shown that their metabolites may have beneficial properties.

NUTRIENTS (2021)

Add to Collection

Article Endocrinology & Metabolism

Diagnosis of Polycystic Ovary Syndrome Which Criteria to Use and When?

Sydney Chang et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2021)

Add to Collection

Article Nutrition & Dietetics

Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats

Geethika S. G. Liyanage et al.

Summary: The study suggests that soy isoflavone metabolites and resistant starch, along with gut microbiota modulations, can reduce the severity of PCOS reproductive features and increase the expression of gut barrier markers and butyric acid. Resistant starch intake can elevate the concentration of butyric acid, but is positively correlated with menstrual irregularity.

NUTRIENTS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Chronic Low Grade Inflammation in Pathogenesis of PCOS

Ewa Rudnicka et al.

Summary: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, often leading to health issues like obesity and insulin resistance. Studies suggest a link between PCOS and chronic inflammation, which may contribute to cardiovascular diseases and other complications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Pharmacology & Pharmacy

Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis

Aynaz Mihanfar et al.

Summary: This study aimed to investigate the mechanisms underlying quercetin's positive effects by modulating key components of energy homeostasis and adipose tissue hormones in rats with letrozole-induced PCOS.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Therapeutic effects of puerarin on polycystic ovary syndrome A randomized trial in Chinese women

Wenjing Li et al.

Summary: The study demonstrated that the addition of puerarin to the treatment protocol for PCOS patients led to significantly improved levels of sex hormone binding globulin and superoxide dismutase. Obese patients with PCOS who received puerarin treatment also showed reductions in systolic blood pressure, total cholesterol, and testosterone levels.

MEDICINE (2021)

Add to Collection

Review Endocrinology & Metabolism

Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment

Elisabet Stener-Victorin et al.

Summary: Polycystic ovary syndrome (PCOS) is a major cause of female infertility worldwide, with high prevalence and economic burden. The etiology of PCOS involves genetic and developmental factors, with hyperandrogenism playing a key role. Current treatments are limited, highlighting the need for more effective preventative and targeted therapies.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Add to Collection

Article Endocrinology & Metabolism

Adverse Effects of Selected Markers on the Metabolic and Endocrine Profiles of Obese Women With and Without PCOS

Mazin H. Daghestani et al.

Summary: The study found that PCOS results in a significant elevation of VEGF in obese females, but does not affect levels of kisspeptin and Vit D. It also leads to an increase in several lipid and hormonal abnormalities in obese females. PCOS influences the relationship between Kisspeptin and VEGF, as well as parameters such as glucose, LH or FSH, and LH/FSH ratio in obese females, while not affecting the relationship of Vit D with other parameters.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Article Food Science & Technology

Exploring the prophylactic role of soy isoflavones against polycystic ovarian syndrome

Nishaf Manzar et al.

Summary: The experiment showed that soy isoflavones (SI) have a significant impact on nutrient absorption, lipid profile, and reproductive hormones in PCOS rat models, especially in reducing cholesterol and increasing HDL levels.

FOOD SCIENCE & NUTRITION (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Soy isoflavones alleviate polycystic ovary syndrome in rats by regulating NF- kappa B signaling pathway

Xiaohong Ma et al.

Summary: Soy isoflavones treatment in PCOS rats significantly reduced body weight, ovarian volume and weight, improved estrous cycle, decreased cystic dilated follicles and atretic follicles in ovarian tissue, reduced testosterone and luteinizing hormone levels, increased estradiol and follicle stimulating hormone levels, inhibited NF-kappa B pathway activity, and enhanced anti-inflammatory and antioxidant capacity, thereby improving ovarian morphology and hormone disorders in PCOS rats.

BIOENGINEERED (2021)

Add to Collection

Review Medical Laboratory Technology

Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity

Xin Zeng et al.

CLINICA CHIMICA ACTA (2020)

Add to Collection

Article Endocrinology & Metabolism

Therapeutic potentials of the natural plant flavonoid apigenin in polycystic ovary syndrome in rat model: via modulation of pro-inflammatory cytokines and antioxidant activity

Parisa Darabi et al.

GYNECOLOGICAL ENDOCRINOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Effects of vitamin D on steroidogenesis, reactive oxygen species production, and enzymatic antioxidant defense in human granulosa cells of normal and polycystic ovaries

Fatemeh Masjedi et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

Add to Collection

Article Endocrinology & Metabolism

Neuropeptide galanin and its effects on metabolic and reproductive disturbances in female rats with estradiol valerate (EV) - Induced polycystic ovary syndrome (PCOS)

Farahnaz Azin et al.

NEUROPEPTIDES (2020)

Add to Collection

Review Reproductive Biology

Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review

Fatemeh Pourteymour Fard Tabrizi et al.

JOURNAL OF OVARIAN RESEARCH (2020)

Add to Collection

Article Chemistry, Medicinal

Effect of liquiritin on neuroendocrine-immune network in menopausal rat model

Xin-Yi Lan et al.

PHYTOTHERAPY RESEARCH (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Meta-analysis: How to quantify and explain heterogeneity?

Todd Ruppar

EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING (2020)

Add to Collection

Article Endocrinology & Metabolism

Androgen signaling pathways driving reproductive and metabolic phenotypes in a PCOS mouse model

Ali Aflatounian et al.

JOURNAL OF ENDOCRINOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

In Search of New Therapeutics-Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond

Agata Wawrzkiewicz-Jalowiecka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing

Waqas Alam et al.

MOLECULES (2020)

Add to Collection

Article Multidisciplinary Sciences

Defining the impact of dietary macronutrient balance on PCOS traits

Valentina Rodriguez Paris et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Integrative & Complementary Medicine

Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice

Ge Hong et al.

CHINESE MEDICINE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Animal Models for Human Polycystic Ovary Syndrome (PCOS) Focused on the Use of Indirect Hormonal Perturbations: A Review of the Literature

Youngjae Ryu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Medical Laboratory Technology

Sex hormone-binding globulin and polycystic ovary syndrome

Jing-ling Zhu et al.

CLINICA CHIMICA ACTA (2019)

Add to Collection

Review Chemistry, Applied

Anti-inflammatory effects of flavonoids

Soheila J. Maleki et al.

FOOD CHEMISTRY (2019)

Add to Collection

Article Obstetrics & Gynecology

The regulation and signalling of anti-Mullerian hormone in human granulosa cells: relevance to polycystic ovary syndrome

Nafi Dilaver et al.

HUMAN REPRODUCTION (2019)

Add to Collection

Article Reproductive Biology

Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase

Wei Wang et al.

JOURNAL OF OVARIAN RESEARCH (2019)

Add to Collection

Review Medicine, General & Internal

New therapeutic approaches for endometriosis besides hormonal therapy

Fang-Ying Chen et al.

CHINESE MEDICAL JOURNAL (2019)

Add to Collection

Article Endocrinology & Metabolism

Baicalin inhibits recruitment of GATA1 to the HSD3B2 promoter and reverses hyperandrogenism of PCOS

Jin Yu et al.

JOURNAL OF ENDOCRINOLOGY (2019)

Add to Collection

Review Medicine, General & Internal

Lifestyle changes in women with polycystic ovary syndrome

Siew S. Lim et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2019)

Add to Collection

Article Obstetrics & Gynecology

Clomiphene Stair-Step Protocol for Women With Polycystic Ovary Syndrome

Tiffanny Jones et al.

OBSTETRICS AND GYNECOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy

Seema Patel

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Add to Collection

Review Endocrinology & Metabolism

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

Hector F. Escobar-Morreale

NATURE REVIEWS ENDOCRINOLOGY (2018)

Add to Collection

Article Reproductive Biology

Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study

Sarwat Jahan et al.

JOURNAL OF OVARIAN RESEARCH (2018)

Add to Collection

Review Endocrinology & Metabolism

New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins

Kirsty A. Walters et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Add to Collection

Article Medicine, General & Internal

Managing polycystic ovary syndrome in primary care

Angelyn Chen Yin Lua et al.

SINGAPORE MEDICAL JOURNAL (2018)

Add to Collection

Review Medicine, General & Internal

Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome

Sebastian Franik et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2018)

Add to Collection

Review Obstetrics & Gynecology

Expression of the gonadotropin receptors during follicular development

Hiroshi Kishi et al.

REPRODUCTIVE MEDICINE AND BIOLOGY (2018)

Add to Collection

Article Plant Sciences

Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism

Ravi Kumar Rajan et al.

PHARMACEUTICAL BIOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat

Tao Hu et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2017)

Add to Collection

Review Endocrinology & Metabolism

Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review

Larissa Paixao et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2017)

Add to Collection

Review Pharmacology & Pharmacy

GLP-1 receptor agonists in the treatment of polycystic ovary syndrome

Elizabeth Mary Lamos et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2017)

Add to Collection

Article Plant Sciences

Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome

Krushangi N. Shah et al.

PHARMACEUTICAL BIOLOGY (2016)

Add to Collection

Article Endocrinology & Metabolism

The Effects of Soy Isoflavones on Metabolic Status of Patients With Polycystic Ovary Syndrome

Mehri Jamilian et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Add to Collection

Article Reproductive Biology

Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats

Sarwat Jahan et al.

JOURNAL OF OVARIAN RESEARCH (2016)

Add to Collection

Article Multidisciplinary Sciences

Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus

Yuehui Zhang et al.

Scientific Reports (2016)

Add to Collection

Review Food Science & Technology

Flavonoids and Immune Function in Human: A Systematic Review

Ilaria Peluso et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2015)

Add to Collection

Article Health Care Sciences & Services

SYRCLE's risk of bias tool for animal studies

Carlijn R. Hooijmans et al.

BMC MEDICAL RESEARCH METHODOLOGY (2014)

Add to Collection

Article Endocrinology & Metabolism

Dysregulation of Ovarian Follicular Development in Female Rat: LH Decreases FSH Sensitivity During Preantral-Early Antral Transition

Makoto Orisaka et al.

ENDOCRINOLOGY (2013)

Add to Collection

Review Cell Biology

The role of low-grade inflammation in the polycystic ovary syndrome

Andrea Repaci et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

Add to Collection

Article Obstetrics & Gynecology

Inappropriate gonadotropin secretion in polycystic ovary syndrome

Ming-I Hsu et al.

FERTILITY AND STERILITY (2009)

Add to Collection

Review Medicine, General & Internal

Metabolic and cardiovascular impact of oral contraceptives in polycystic ovary syndrome

G. M. Soares et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2009)

Add to Collection

Review Medicine, General & Internal

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

Alessandro Liberati et al.

BMJ-BRITISH MEDICAL JOURNAL (2009)

Add to Collection

Review Obstetrics & Gynecology

Follicle dynamics and anovulation in polycystic ovary syndrome

Stephen Franks et al.

HUMAN REPRODUCTION UPDATE (2008)

Add to Collection

Review Plant Sciences

Flavonoid oxidation in plants: from biochemical properties to physiological functions

Lucille Pourcel et al.

TRENDS IN PLANT SCIENCE (2007)

Add to Collection

Article Obstetrics & Gynecology

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

BCJM Fauser et al.

HUMAN REPRODUCTION (2004)

Add to Collection

Review Biochemistry & Molecular Biology

Anthocyanins and other flavonoids

CA Williams et al.

NATURAL PRODUCT REPORTS (2004)

Add to Collection

Article Obstetrics & Gynecology

Effects of exogenous LH administration during ovarian stimulation of pituitary down-regulated young oocyte donors on oocyte yield and developmental competence

J Tesarik et al.

HUMAN REPRODUCTION (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.