Journal
NUTRIENTS
Volume 14, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/nu14214552
Keywords
NAFLD; Chiliadenus iphionoides; lipid metabolism; glucose tolerance
Categories
Funding
- Israeli Ministry of Agriculture and Rural Development [31-37-0002]
- Israeli Ministry of Science and Technology
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This study found that supplementing high-fat diet with C. iphionoides can improve metabolic effects in a NAFLD model. Consumption of C. iphionoides can reduce weight gain, liver and adipose tissue weights, and improve liver function and lipid metabolism.
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic with increasing prevalence. Limited treatment options and poor adherence emphasize the urgent need for novel therapies for the treatment and/or prevention of NAFLD. Bioactive natural compounds found in medicinal plants are promising as novel therapeutic agents for NAFLD. Chiliadenus iphionoides, a medicinal plant with several health-promoting properties, is an encouraging candidate. The current study aimed to elucidate the metabolic effects of C. iphionoides consumption in a high-fat-diet (HFD)-induced model of NAFLD. Male C57BL/6J mice (n = 40, 7-8-week-old) were fed a HFD (60% fat) with/without 0.5 or 2.5 gr C. iphionoides for fifteen weeks. Diet supplementation with C. iphionoides significantly ameliorated HFD-induced weight gain. Likewise, liver and adipose tissue weights were profoundly lower in the C. iphionoides-fed groups. Reduced liver steatosis in those groups was corroborated by histology, plasma liver enzyme levels, and lipid profile, indicating improved liver function and lipid metabolism in addition to enhanced insulin sensitivity. The addition of C. iphionoides to an obesogeneic diet can beneficially alleviate metabolic alterations and may be a practicable strategy for the management of NAFLD.
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