4.7 Article

Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Relationship between circulating netrin-1 levels, obesity, prediabetes and newly diagnosed type 2 diabetes

Iveta Nedeva et al.

Summary: This study found that netrin-1 is associated with an increased risk for glycaemic disorders in patients with obesity. Circulating serum netrin-1 levels were significantly lower in patients with obesity, as well as in those with prediabetes and diabetes.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Netrin-1: An emerging player in inflammatory diseases

Xueli Xia et al.

Summary: Netrin-1, a chemotactic molecule, participates in cell movement and axonal guidance during embryonic development, as well as potentially regulating angiogenesis, inflammation, tissue remodeling, and cancer. Through interactions with its receptors, Netrin-1 plays varied roles in different physiological pathways, exerting different effects on various physiological and pathophysiological processes.

CYTOKINE & GROWTH FACTOR REVIEWS (2022)

Article Endocrinology & Metabolism

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provide clinical practice recommendations, treatment goals, and tools for evaluating the quality of care in diabetes management.

DIABETES CARE (2022)

Review Biochemistry & Molecular Biology

Netrin-1: A Modulator of Macrophage Driven Acute and Chronic Inflammation

Laura Ziegon et al.

Summary: Netrin-1 plays a crucial role in various biological processes, including cell adhesion, migration, proliferation, and survival. It has a dual role in both acute and chronic inflammation, influencing leukocyte migration and macrophage function.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Medicine, General & Internal

Reassessing Human Adipose Tissue

Aaron M. Cypess

Summary: This review reevaluates human adipose tissue, discussing its roles in obesity and its important complementary functions in the endocrine system.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Medicine, General & Internal

'Obesities': Position statement on a complex disease entity with multifaceted drivers

Patricia Yarnoz-Esquiroz et al.

Summary: Academic medicine aims to promote research that moves from discovery to translation and educate the next generation of professionals. However, in the field of obesity, integration of knowledge and translation research is hindered by the inability of the body mass index classification to account for multiple subtypes of obesity, and the lack of a universally shared definition, which prevents the determination of the true burden of different obesity phenotypes.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Gastroenterology & Hepatology

Hepatic inflammation elicits production of proinflammatory netrin-1 through exclusive activation of translation

Romain Barnault et al.

Summary: This study identifies Netrin-1 as an inflammation-inducible factor in the liver and reveals its contribution to hepatic inflammation through an atypical mechanism. Additionally, the study finds that an anti-Netrin-1 antibody has anti-inflammatory activity in hepatic inflammation.

HEPATOLOGY (2022)

Review Nutrition & Dietetics

Time to Consider the Exposome Hypothesis in the Development of the Obesity Pandemic

Victoria Catalan et al.

Summary: The main causes of the obesity epidemic are genetics and overnutrition, along with a decline in physical activity. However, there may be other factors, referred to as the exposome, that contribute to obesity. Broad interventions are needed to better identify and understand these factors.

NUTRIENTS (2022)

Article Immunology

Serum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity

Gema Fruehbeck et al.

Summary: The study compared IL-1RA levels in individuals with different weight statuses and analyzed its association with adipose tissue dysfunction. The results showed a significant increase in IL-1RA levels in individuals with obesity, particularly in the group associated with impaired glucose tolerance and type 2 diabetes. IL1RN mRNA expression in adipose tissue also increased, correlating with the expression of inflammation-related genes.

JOURNAL OF INFLAMMATION RESEARCH (2022)

Article Surgery

Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery

Anne Lautenbach et al.

Summary: Bariatric surgery can reduce obesity-related chronic low-grade inflammation for up to 4 years after the surgery, with improvement related to changes in BMI and remission of T2D in the long-term.

OBESITY SURGERY (2021)

Article Biochemistry & Molecular Biology

Hypoxia-inducible factor-dependent induction of myeloid-derived netrin-1 attenuates natural killer cell infiltration during endotoxin-induced lung injury

Nathaniel K. Berg et al.

Summary: The study revealed the crucial role of the neuronal guidance protein netrin-1 in controlling lung inflammation by modulating CCL2-dependent infiltration of NK cells during LPS-induced lung injury. Deletion of netrin-1 in the myeloid compartment led to exacerbated lung inflammation and increased mortality rates.

FASEB JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression

Martin Schlegel et al.

Summary: Targeting Ntn1 in advanced atherosclerosis can ameliorate atherosclerotic inflammation and promote plaque regression by restructuring monocyte-macrophage dynamics and enhancing pathways involved in inflammation resolution.

CIRCULATION RESEARCH (2021)

Article Immunology

IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation

Yu-Hsiang Hsu et al.

Summary: IL-20 plays a critical role in obesity-induced inflammation and insulin resistance by regulating various pathways. It shows potential as a novel target for treating obesity and insulin resistance in patients with metabolic disorders.

IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery

Jose Romeo Villarreal-Calderon et al.

Summary: Bariatric and metabolic surgery can promote weight loss and reduce systemic inflammation. The study found that improvements in metabolic markers occurred before the resolution of systemic inflammation after surgery. Inflammatory markers such as hs-CRP, TNF-alpha, IL-1 beta, IL-6, and IL-8 decreased significantly 6 months after surgery.

SCIENTIFIC REPORTS (2021)

Article Cardiac & Cardiovascular Systems

Metabolic Inflammation and Insulin Resistance in Obesity

Huaizhu Wu et al.

CIRCULATION RESEARCH (2020)

Article Medicine, Research & Experimental

Netrin-1 reduces lung ischemia-reperfusion injury by increasing the proportion of regulatory T cells

Zhili Chen et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

Review Medicine, General & Internal

Adipokine dysregulation and adipose tissue inflammation in human obesity

Xabier Unamuno et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Endocrinology & Metabolism

Novel protective role of kallistatin in obesity by limiting adipose tissue low grade inflammation and oxidative stress

Gema Fruhbeck et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

Article Biochemistry & Molecular Biology

Netrin-1 prevents the attachment of monocytes to endothelial cells via an anti-inflammatory effect

Zhaoheng Lin et al.

MOLECULAR IMMUNOLOGY (2018)

Review Endocrinology & Metabolism

Adapting to obesity with adipose tissue inflammation

Shannon M. Reilly et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Medicine, General & Internal

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

Ashkan Afshin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medical Laboratory Technology

Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes

Emre Ay et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2016)

Article Endocrinology & Metabolism

The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients

Chenxiao Liu et al.

BMC ENDOCRINE DISORDERS (2016)

Article Biochemistry & Molecular Biology

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

Bhama Ramkhelawon et al.

NATURE MEDICINE (2014)

Article Hematology

Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques Mechanism for Macrophage Retention and Survival

Bhama Ramkhelawon et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Editorial Material Cell Biology

The Semaphorin 3E/PlexinD1 Axis Regulates Macrophage Inflammation in Obesity

Ann Marie Schmidt et al.

CELL METABOLISM (2013)

Article Genetics & Heredity

Protective role for netrin-1 during diabetic nephropathy

Eunyoung Tak et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2013)

Article Physiology

Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization

Punithavathi Vilapakkam Ranganathan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Review Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease: Pathologic Patterns and Biopsy Evaluation in Clinical Research

David E. Kleiner et al.

SEMINARS IN LIVER DISEASE (2012)

Article Endocrinology & Metabolism

Insulin- and Leptin-Mediated Control of Aquaglyceroporins in Human Adipocytes and Hepatocytes Is Mediated via the PI3K/Akt/mTOR Signaling Cascade

Amaia Rodriguez et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Multidisciplinary Sciences

Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity

Marina R. Pulido et al.

PLOS ONE (2011)

Review Immunology

Adipokines in inflammation and metabolic disease

Noriyuki Ouchi et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

Netrin-1 inhibits leukocyte migration in vitro and in vivo

NP Ly et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Medicine, Research & Experimental

Obesity is associated with macrophage accumulation in adipose tissue

SP Weisberg et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Endocrinology & Metabolism

Immunocytochemical detection of leptin in non-mammalian vertebrate stomach

FJ Muruzábal et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2002)