4.7 Article

Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE-/- Mice Fed High-Fat Diet

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

Immune Mechanisms of Plaque Instability

Teresa Gerhardt et al.

Summary: This review discusses the crucial role of inflammation in atherosclerosis-related diseases and explores key immune cells and other maladaptive immune phenomena that contribute to plaque instability and disruption. In addition, it addresses the impact of systemic crises, COVID-19 disease, and gut dysbiosis on atherosclerosis progression. The review also summarizes the differential role of the immune system in plaque rupture and erosion, as well as the limitations of animal models.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Article Biochemistry & Molecular Biology

Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling

Ben Li et al.

Summary: Rutin inhibits inflammation and foam cell formation associated with atherosclerosis by inducing autophagy and modulating the PI3K/ATK signaling pathway.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine

ShuangSang Fang et al.

Summary: Pharmacotranscriptomics has been used to evaluate drug efficacy and discover new drug targets. In the field of traditional Chinese medicine (TCM), there is a growing trend towards high-throughput transcriptomic screens for molecular effects of herbs/ingredients. HERB is a database that integrates gene targets for TCM herbs/ingredients and modern drugs, supporting the modernization of TCM and rational drug discovery efforts.

NUCLEIC ACIDS RESEARCH (2021)

Review Pharmacology & Pharmacy

The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review

Jessica Silva dos Santos et al.

Summary: Kaempferol, a flavonoid antioxidant found in fruits and vegetables, has shown neuroprotective effects in the central nervous system through modulation of proinflammatory signaling pathways. The differences in biological benefits and pharmacokinetic behaviors between KPF aglycone and its glycosides are notable. Future studies are needed to clarify the mechanisms of Kaempferol's action in CNS diseases and the impact of glycosylation on its bioactivity.

FRONTIERS IN PHARMACOLOGY (2021)

Article Plant Sciences

Qing-Xue-Xiao-Zhi formula attenuates atherosclerosis by inhibiting macrophage lipid accumulation and inflammatory response via TLR4/MyD88/NF-κB pathway regulation

Yue Li et al.

Summary: Our study demonstrates that Qing-Xue-Xiao-Zhi formula (QXXZF) has a significant inhibitory effect on the development of atherosclerosis in ApoE(-/-) mice fed a high-fat and high-choline diet, with decreased atherosclerotic plaques, plasma lipid levels, and serum TMAO content. Additionally, QXXZF effectively reduces foam cell formation and promotes reverse cholesterol transport in macrophages, influencing cholesterol metabolism by inhibiting the TLR4-mediated NF-kappa B axis. These findings provide new insights into the anti-atherosclerotic mechanisms of QXXZF.

PHYTOMEDICINE (2021)

Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

Article Multidisciplinary Sciences

Gasdermin D pore structure reveals preferential release of mature interleukin-1

Shiyu Xia et al.

Summary: Inflammasomes activate caspase-1 to cleave GSDMD and generate mature cytokines like IL-1 beta and IL-18, which are released through pores formed by GSDMD. The GSDMD pore mediates IL-1 release by electrostatic filtering, favoring the passage of mature cytokines over their precursors.

NATURE (2021)

Review Cardiac & Cardiovascular Systems

TRPC5 in cardiovascular diseases

Sheng-Li Du et al.

Summary: Cardiovascular diseases, especially acute myocardial infarction, are the leading cause of death, morbidity and disability globally. Atherosclerosis is a major cause of cardiovascular diseases, and factors like TRPC5 play crucial roles in the pathogenesis of cardiovascular diseases.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis - Novel insights and future directions in diagnosis and therapy

Adam Hartley et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

Review Immunology

Vascular Macrophages in Atherosclerosis

Hailin Xu et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2019)

Article Hematology

Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association

Connie B. Newman et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Immunity and Inflammation in Atherosclerosis

Dennis Wolf et al.

CIRCULATION RESEARCH (2019)

Review Pathology

Potential of anti-inflammatory agents for treatment of atherosclerosis

Dimitry A. Chistiakov et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2018)

Review Plant Sciences

Applications of Higenamine in pharmacology and medicine

Nana Zhang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Hypertriglyceridemia and atherosclerosis

Jia Peng et al.

LIPIDS IN HEALTH AND DISEASE (2017)

Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

Ira Tabas et al.

CIRCULATION RESEARCH (2016)

Review Biochemistry & Molecular Biology

Atherosclerosis: the interplay between lipids and immune cells

Frank Schaftenaar et al.

CURRENT OPINION IN LIPIDOLOGY (2016)

Review Biochemistry & Molecular Biology

Immune-mediated and lipid-mediated platelet function in atherosclerosis

Maiwand Ahmadsei et al.

CURRENT OPINION IN LIPIDOLOGY (2015)

Review Cell Biology

Recent insights into the cellular biology of atherosclerosis

Ira Tabas et al.

JOURNAL OF CELL BIOLOGY (2015)

Article Medical Laboratory Technology

Low Nonfasting Triglycerides and Reduced All-Cause Mortality: A Mendelian Randomization Study

Mette Thomsen et al.

CLINICAL CHEMISTRY (2014)

Article Food Science & Technology

Multiple pathways are involved in palmitic acid-induced toxicity

Eun-Jung Park et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Adenosine Physiology, Pharmacology, and Clinical Applications

Jamie Layland et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2014)

Article Cardiac & Cardiovascular Systems

TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ

Youzhi Zhang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

Article Biology

Antioxidant effect of mogrosides against oxidative stress induced by palmitic acid in mouse insulinoma NIT-1 cells

Q. Xu et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2013)

Review Integrative & Complementary Medicine

Network Pharmacology: A New Approach for Chinese Herbal Medicine Research

Gui-biao Zhang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Peripheral Vascular Disease

Residual Cardiovascular Risk Despite Optimal LDL Cholesterol Reduction with Statins: The Evidence, Etiology, and Therapeutic Challenges

Uchechukwu K. Sampson et al.

CURRENT ATHEROSCLEROSIS REPORTS (2012)

Article Peripheral Vascular Disease

Regulation of Atherosclerosis and Associated Risk Factors by Adenosine and Adenosine Receptors

Milka Koupenova et al.

CURRENT ATHEROSCLEROSIS REPORTS (2012)

Article Multidisciplinary Sciences

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1

Jenny E. Kanter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cardiac & Cardiovascular Systems

Regression of Atherosclerosis

Benoit J. Arsenault et al.

CURRENT CARDIOLOGY REPORTS (2012)

Review Medicine, General & Internal

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy A Meta-analysis

David Preiss et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Review Medicine, Research & Experimental

Role of TNF-α in vascular dysfunction

Hanrui Zhang et al.

CLINICAL SCIENCE (2009)

Review Cardiac & Cardiovascular Systems

Animal models and potential mechanisms of plaque destabilisation and disruption

M. Ni et al.

HEART (2009)

Review Cardiac & Cardiovascular Systems

Cytokines and atherosclerosis: a comprehensive review of studies in mice

Robert Kleemann et al.

CARDIOVASCULAR RESEARCH (2008)

Article Medicine, Research & Experimental

TLRs are important inflammatory factors in atherosclerosis and may be a therapeutic target

Yunfang Liu et al.

MEDICAL HYPOTHESES (2008)

Article Medicine, General & Internal

Simvastatin with or without ezetimibe in familial hypercholesterolemia

John J. P. Kastelein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Agriculture, Multidisciplinary

Antiatherogenic effects of kaempferol and rhamnocitrin

Yi-Chen Tu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)

Review Cardiac & Cardiovascular Systems

Macrophage reverse cholesterol transport - Key to the regression of atherosclerosis?

Marina Cuchel et al.

CIRCULATION (2006)

Review Hematology

Dietary factors that promote or retard inflammation

A Basu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

Article Medicine, Research & Experimental

Inflammation may be a bridge connecting hypertension and atherosclerosis

JJ Li et al.

MEDICAL HYPOTHESES (2005)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Article Immunology

IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells

K Tominaga et al.

INTERNATIONAL IMMUNOLOGY (2000)