4.8 Article

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

TheBio3Dpackages for structural bioinformatics

Barry J. Grant et al.

Summary: Bio3D is a set of R packages for analyzing biomolecular sequences, structures, and dynamics, with recent developments including segregation into separate packages and introduction of a new method called ensemble difference distance matrix analysis (eDDM). The eDDM approach helps identify residue-wise determinants underlying specific functional processes by calculating and comparing atomic distance matrices across large sets of homologous structures.

PROTEIN SCIENCE (2021)

Article Biochemistry & Molecular Biology

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

Eric F. Pettersen et al.

Summary: UCSF ChimeraX is a powerful visualization program with enhanced performance and graphics, offering new tools and analysis features, support for various areas like virtual reality, and improved ease of use, along with an app store for researchers to contribute new tools.

PROTEIN SCIENCE (2021)

Article Pathology

Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy

Edward Dere et al.

Summary: FHTR2163, an antigen-binding fragment of a humanized monoclonal antibody targeting HTRA1, showed good tolerability in both single-dose and repeat-dose intravitreal administration studies in cynomolgus monkeys. Transient and reversible ocular effects, such as inflammation and perivascular infiltrates, were observed, indicating an immune response. This nonclinical package supports the further clinical development of FHTR2163 for geographic atrophy in patients.

TOXICOLOGIC PATHOLOGY (2021)

Article Ophthalmology

Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration

Arshad M. Khanani et al.

Summary: The study demonstrated that FHTR2163, a novel Fab targeting HtrA1, was well tolerated and showed sustained pharmacodynamic effect at the maximum tested dose. There were no clinically significant ocular changes observed and no dose limiting toxicities were reported.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2021)

Article Biochemistry & Molecular Biology

A distinct concerted mechanism of structural dynamism defines activity of human serine protease HtrA3

Saujanya Acharya et al.

BIOCHEMICAL JOURNAL (2020)

Review Ophthalmology

Risk factors for progression of age-related macular degeneration

Thomas J. Heesterbeek et al.

OPHTHALMIC AND PHYSIOLOGICAL OPTICS (2020)

Article Multidisciplinary Sciences

Activation by substoichiometric inhibition

Melisa Merdanovic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

Irene Tom et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge

Henry R. Maun et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

Henry R. Maun et al.

Article Biochemistry & Molecular Biology

MolProbity: More and better reference data for improved all-atom structure validation

Christopher J. Williams et al.

PROTEIN SCIENCE (2018)

Article Biochemistry & Molecular Biology

Genome-wide analysis of disease progression in age-related macular degeneration

Qi Yan et al.

HUMAN MOLECULAR GENETICS (2018)

Article Ophthalmology

The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration

Monika Fleckenstein et al.

OPHTHALMOLOGY (2018)

Article Biochemistry & Molecular Biology

Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer

Qiaoying Lv et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemical Research Methods

New tools for the analysis and validation of cryo-EM maps and atomic models

Pavel V. Afonine et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

Article Biochemistry & Molecular Biology

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists

Yingnan Zhang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Cell Biology

Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2

Matthew Merski et al.

CELL DEATH & DISEASE (2017)

Article Biochemistry & Molecular Biology

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists

Yingnan Zhang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Multidisciplinary Sciences

Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator

Tobias Kromann-Hansen et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

Alvaro Cortes Cabrera et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases

Hui-Gwan Goo et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2017)

Article Biochemistry & Molecular Biology

Structural insights into the activation mechanisms of human HtrA serine proteases

Dorota Zurawa-Janicka et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)

Article Biochemistry & Molecular Biology

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

Haim Ashkenazy et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody

Claudio Ciferri et al.

BIOCHEMICAL JOURNAL (2015)

Article Chemistry, Physical

Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning

Chad W. Hopkins et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)

Article Biochemistry & Molecular Biology

Determinants of amyloid fibril degradation by the PDZ protease HTRA1

Simon Poepsel et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

Przemyslaw Glaza et al.

PLOS ONE (2015)

Article Multidisciplinary Sciences

Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports

Joel R. Meyerson et al.

SCIENTIFIC REPORTS (2014)

Article Biochemistry & Molecular Biology

Rezymogenation of active urokinase induced by an inhibitory antibody

Longguang Jiang et al.

BIOCHEMICAL JOURNAL (2013)

Article Pharmacology & Pharmacy

HtrA Protease Family as Therapeutic Targets

Joanna Skorko-Glonek et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Article Biochemistry & Molecular Biology

Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2

Lalith K. Chaganti et al.

FASEB JOURNAL (2013)

Article Chemistry, Physical

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

Daniel R. Roe et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Biochemistry & Molecular Biology

Allosteric antibody inhibition of human hepsin protease

Tobias Koschubs et al.

BIOCHEMICAL JOURNAL (2012)

Article Biochemistry & Molecular Biology

A Bayesian View on Cryo-EM Structure Determination

Sjors H. W. Scheres

JOURNAL OF MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Structural and Functional Analysis of HtrA1 and Its Subdomains

Charles Eigenbrot et al.

STRUCTURE (2012)

Review Cell Biology

HTRA proteases: regulated proteolysis in protein quality control

Tim Clausen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Substrate-induced remodeling of the active site regulates human HTRA1 activity

Linda Truebestein et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

Po-Ssu Huang et al.

PLOS ONE (2011)

Article Biochemical Research Methods

XDS

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Review Biochemistry & Molecular Biology

Structural and mechanistic insight into how antibodies inhibit serine proteases

Rajkumar Ganesan et al.

BIOCHEMICAL JOURNAL (2010)

Article Biotechnology & Applied Microbiology

Emerging principles in protease-based drug discovery

Marcin Drag et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Review Oncology

HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

Jeremy Chien et al.

CURRENT CANCER DRUG TARGETS (2009)

Article Biochemistry & Molecular Biology

A Novel Mode of Intervention with Serine Protease Activity TARGETING ZYMOGEN ACTIVATION

Grant E. Blouse et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Medicine, General & Internal

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

Kenju Hara et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Biochemistry & Molecular Biology

Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody

Rajkumar Ganesan et al.

STRUCTURE (2009)

Review Rheumatology

Emerging Roles of Serine Proteinases in Tissue Turnover in Arthritis

J. M. Milner et al.

ARTHRITIS AND RHEUMATISM (2008)

Article Chemistry, Multidisciplinary

Phaser crystallographic software

Airlie J. McCoy et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)

Article Multidisciplinary Sciences

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

Zhenglin Yang et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

HTRA1 promoter polymorphism in wet age-related macular degeneration

Andrew DeWan et al.

SCIENCE (2006)

Article Medicine, Research & Experimental

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

Jeremy Chien et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Biochemistry & Molecular Biology

The role of human HtrA1 in arthritic disease

S Grau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Automated electron microscope tomography using robust prediction of specimen movements

DN Mastronarde

JOURNAL OF STRUCTURAL BIOLOGY (2005)

Article Multidisciplinary Sciences

Implications of the serine protease HtrA1 in amyloid precursor protein processing

S Grau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Complement factor H polymorphism and age-related macular degeneration

AO Edwards et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

Complement factor H variant increases the risk of age-related macular degeneration

JL Haines et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer

J Chien et al.

ONCOGENE (2004)

Review Biochemistry & Molecular Biology

The HtrA family of proteases: Implications for protein composition and cell fate

T Clausen et al.

MOLECULAR CELL (2002)

Article Biochemistry & Molecular Biology

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

WY Li et al.

NATURE STRUCTURAL BIOLOGY (2002)

Article Multidisciplinary Sciences

Tryptophan zippers:: Stable, monomeric β-hairpins

AG Cochran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Peptide exosite inhibitors of factor VIIa as anticoagulants

MS Dennis et al.

NATURE (2000)