Functional genomics of complex cancer genomes

Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities beyond the original paradigm of one gene-one phenotype.

Automated summary

Cancer functional genomics explores how genetic, epigenetic, and transcriptional changes impact cancer phenotypes, using next generation sequencing and systems biology to uncover novel cancer vulnerabilities beyond the traditional one gene-one phenotype paradigm.