Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage

Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant removal and storage stability. We demonstrate a significantly improved hemostatic efficacy and biocompatibility in rats and pigs compared to non-structured counterparts and commercial products. This work opens new avenues for the development of bioadhesives and hemostatic sealants. Non-compressible wounds are a major source of high mortality in trauma victims. Here the authors report on the creation of xerogels impregnated with liquid adhesives which can rapidly absorb fluids promoting blood clotting while forming adhesions to tissue and demonstrate the xerogel in ex vivo and in vivo models.

Automated summary

Non-compressible hemorrhage is a challenge in trauma patients, but researchers have developed a new type of bioadhesive that can rapidly absorb fluids promoting blood clotting and demonstrate good adhesion and hemostatic effects in ex vivo and in vivo models.