Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-32670-w
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Funding
- SNSF fellowship [PZ00P3-185926]
- UNIL-CHUV fellowship
- PROMEDICA Stiftung
- Swiss National Science Foundation (SNF) [PZ00P3_185926] Funding Source: Swiss National Science Foundation (SNF)
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By utilizing single-cell and spatial transcriptomics, this study identifies the cellular contributors and their transcriptional reprogramming in the spatial organization of the invasive niche in basal cell carcinomas. The findings demonstrate the potential of integrated multi-omics approaches in deciphering cancer-specific invasive properties and developing targeted therapies.
Tumors invade the surrounding tissues to progress, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential interactions hampered mechanistic insight required for efficient therapeutic targeting. Here, combining single-cell and spatial transcriptomics on human basal cell carcinomas, we define the cellular contributors of tumor progression. In the invasive niche, tumor cells exhibit a collective migration phenotype, characterized by the expression of cell-cell junction complexes. In physical proximity, we identify cancer-associated fibroblasts with extracellular matrix-remodeling features. Tumor cells strongly express the cytokine Activin A, and increased Activin A-induced gene signature is found in adjacent cancer-associated fibroblast subpopulations. Altogether, our data identify the cell populations and their transcriptional reprogramming contributing to the spatial organization of the basal cell carcinoma invasive niche. They also demonstrate the power of integrated spatial and single-cell multi-omics to decipher cancer-specific invasive properties and develop targeted therapies. The role of reciprocal tumour-stroma interactions in tumour invasion remains poorly characterised. Here, single-cell and spatial transcriptomics identifies the cell populations and their transcriptional reprogramming contributing to the spatial organization of the basal cell carcinoma invasive niche.
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