4.8 Article

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

Journal

NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41467-022-32523-6

Keywords

-

Funding

  1. SNF [310030_179163/1]
  2. Biltema ISREC Foundation Cancera Stiftelsen
  3. Mats Paulssons Stiftelse
  4. Stiftelsen Stefan Paulssons Cancerfond
  5. Deutsche Krebshilfe
  6. H2020-MSCA-ITN [ITN-2019-859860-CANCERPREV]
  7. [KFS-4738-02-2019-R]

Ask authors/readers for more resources

This study provides a new method to study the dormant state of estrogen receptor alpha-positive breast cancer (ER+ BC) and reveals the underlying mechanisms. The researchers found that disseminated ER+ BC cells proliferate slower and exhibit characteristics of epithelial-mesenchymal plasticity, which are crucial for maintaining the dormant state. They also discovered that forced expression of E-cadherin allows ER+ BC cells to overcome dormancy.
More than 70% of human breast cancers (BCs) are estrogen receptor alpha-positive (ER+). A clinical challenge of ER+ BC is that they can recur decades after initial treatments. Mechanisms governing latent disease remain elusive due to lack of adequate in vivo models. We compare intraductal xenografts of ER+ and triple-negative (TN) BC cells and demonstrate that disseminated TNBC cells proliferate similarly as TNBC cells at the primary site whereas disseminated ER+ BC cells proliferate slower, they decrease CDH1 and increase ZEB1,2 expressions, and exhibit characteristics of epithelial-mesenchymal plasticity (EMP) and dormancy. Forced E-cadherin expression overcomes ER+ BC dormancy. Cytokine signalings are enriched in more active versus inactive disseminated tumour cells, suggesting microenvironmental triggers for awakening. We conclude that intraductal xenografts model ER + BC dormancy and reveal that EMP is essential for the generation of a dormant cell state and that targeting exit from EMP has therapeutic potential. The study of tumour dormancy is limited by suitable in vivo models. Here the authors show that mammary intraductal breast cancer (BC) xenografts model estrogen receptor alpha-positive (ER+) BC dormancy and rapid metastatic progression characteristic of triple-negative (TN) BC. The dormant disseminated ER+ BC cells display characteristics of epithelial-mesenchymal plasticity and forced expression of E-cadherin allows them to overcome dormancy.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available