Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-32595-4
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Funding
- National Science Foundation [ACI-1548562]
- NIH [R01 NS120954]
- 16 NIH Institutes and Centers [1U54MH091657]
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This study constructed a connectome that quantifies the probability of white matter tracts innervating cortical regions, and revealed different networks and fiber bundle systems based on hierarchical clustering analysis.
Connectome maps region-to-region connectivities but does not inform which white matter pathways form the connections. Here we constructed a population-based tract-to-region connectome to fill this information gap. The constructed connectome quantifies the population probability of a white matter tract innervating a cortical region. The results show that similar to 85% of the tract-to-region connectome entries are consistent across individuals, whereas the remaining (similar to 15%) have substantial individual differences requiring individualized mapping. Further hierarchical clustering on cortical regions revealed dorsal, ventral, and limbic networks based on the tract-to-region connective patterns. The clustering results on white matter bundles revealed the categorization of fiber bundle systems in the association pathways. This tract-to-region connectome provides insights into the connective topology between cortical regions and white matter bundles. The derived hierarchical relation further offers a categorization of gray and white matter structures.
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