Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-33536-x
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Funding
- Whitehall Foundation [K23NS104252, R01 MH117777]
- (L.dl.P) European Research Council [5F31NS120783-02, 1U19NS104590, R01NS106611-02, MTEC-20-06-MOM-013, 1U19NS107609-01, 1U19NS107609, LCF/PR/HR21/52410030]
- U.S.-Israel BSF [101001121]
- NSF CAREER [2017015]
- Fondation pour la Recherche Medicale [IOS-1844935, 1R01NS121764-01, R01 MH122391, F30MH126483]
- [EQU202103012768]
- [1R16-NS131108-01]
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This article discusses the methodological challenges in detecting, analyzing, and reporting Sharp Wave Ripples, and suggests practical solutions to distinguish them from other high-frequency events. It emphasizes the importance of establishing shared experimental, detection, and reporting standards.
Decades of rodent research have established the role of hippocampal sharp wave ripples (SPW-Rs) in consolidating and guiding experience. More recently, intracranial recordings in humans have suggested their role in episodic and semantic memory. Yet, common standards for recording, detection, and reporting do not exist. Here, we outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations. We argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery. While the contribution of sharp wave ripples in memory consolidation and decision-making is established in rodent models, our understanding of their role in human memory is incomplete. Here, the authors discuss common methodological challenges in detecting, analyzing, and reporting sharp wave ripples, then they suggest practical solutions to distinguish them from other high-frequency events
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