4.5 Article

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues

Journal

EPIGENOMICS
Volume 14, Issue 18, Pages 1105-1124

Publisher

FUTURE MEDICINE LTD
DOI: 10.2217/epi-2022-0228

Keywords

developmental origins of health and disease hypothesis; DNA methylation; imprinting; metastable epiallele; nc886; noncoding 886; polymorphic imprinting; population studies; VTRNA2-1

Funding

  1. Academy of Finland [349708, 341750, 346509, 275323, 309504, 314181, 335249, 297908, 328685, 330809, 338395, 322098, 286284, 134309, 126925, 121584, 124282, 129378, 117787, 41071, 277079]
  2. European Research Council [742927]
  3. Juho Vainio Foundation
  4. Karolinska Institutet Strategic Research Program in Epidemiology
  5. Pirkanmaa Regional Fund of Finnish Cultural Foundation
  6. Pa ivikki and Sakari Sohlberg foundation
  7. Signe och Ane Gyllenbergs stiftelse
  8. Swedish Research Council [2015-03255, 2019-01272, 2020-06101]
  9. Sigrid Juselius Foundation
  10. Tampere University Hospital Medical Funds [9AC077, 9X047, 9S054]
  11. YrjoJahnsson Foundation [20207299, 20217416, 20197181, 20197212]
  12. Social Insurance Institution of Finland
  13. Laboratoriolaaketieteen edistamissaatiosr
  14. Competitive State Research Financing of the Expert Responsibility area of Kuopio University Hospital [X51001]
  15. Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital [X51001]
  16. Competitive State Research Financing of the Expert Responsibility area of Turku University Hospital [X51001]
  17. Paavo Nurmi Foundation
  18. Finnish Foundation for Cardiovascular Research
  19. Finnish Cultural Foundation
  20. Tampere Tuberculosis Foundation
  21. Emil Aaltonen Foundation
  22. YrjoJahnsson Foundation
  23. Signe and Ane Gyllenberg Foundation
  24. Diabetes Research Foundation of Finnish Diabetes Association
  25. EU Horizon 2020 [755320, 848146]
  26. Tampere University Hospital Supporting Foundation
  27. European Union [305739]
  28. German Federal Ministry of Education and Research [01EA1411A]
  29. Pirkanmaa hospital district [9R030, 9S034, 9M053]
  30. Helmholtz Zentrum Munchen - German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
  31. State of Bavaria
  32. Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
  33. Academy of Finland (AKA) [277079, 328685, 277079, 328685, 335249] Funding Source: Academy of Finland (AKA)

Ask authors/readers for more resources

This study characterized the methylation level of the polymorphically imprinted gene VTRNA2-1/nc886 in human populations and somatic tissues, revealing stable methylation status across populations and somatic tissues with minor variations in specific tissues. The twin data suggested that the imprint of the nc886 gene may be established in the oocyte.
Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas similar to 30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues. Tweetable abstract Methylation status of a polymorphically imprinted gene, VTRNA2-1/nc886, is stable in human populations (48 cohorts, n > 30,000) and in somatic tissues, except in cerebellum and skeletal muscle. Twin data suggest it may already be established in the oocyte.

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