Journal
EPIGENOMICS
Volume 14, Issue 18, Pages 1105-1124Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2022-0228
Keywords
developmental origins of health and disease hypothesis; DNA methylation; imprinting; metastable epiallele; nc886; noncoding 886; polymorphic imprinting; population studies; VTRNA2-1
Categories
Funding
- Academy of Finland [349708, 341750, 346509, 275323, 309504, 314181, 335249, 297908, 328685, 330809, 338395, 322098, 286284, 134309, 126925, 121584, 124282, 129378, 117787, 41071, 277079]
- European Research Council [742927]
- Juho Vainio Foundation
- Karolinska Institutet Strategic Research Program in Epidemiology
- Pirkanmaa Regional Fund of Finnish Cultural Foundation
- Pa ivikki and Sakari Sohlberg foundation
- Signe och Ane Gyllenbergs stiftelse
- Swedish Research Council [2015-03255, 2019-01272, 2020-06101]
- Sigrid Juselius Foundation
- Tampere University Hospital Medical Funds [9AC077, 9X047, 9S054]
- YrjoJahnsson Foundation [20207299, 20217416, 20197181, 20197212]
- Social Insurance Institution of Finland
- Laboratoriolaaketieteen edistamissaatiosr
- Competitive State Research Financing of the Expert Responsibility area of Kuopio University Hospital [X51001]
- Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital [X51001]
- Competitive State Research Financing of the Expert Responsibility area of Turku University Hospital [X51001]
- Paavo Nurmi Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Cultural Foundation
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- YrjoJahnsson Foundation
- Signe and Ane Gyllenberg Foundation
- Diabetes Research Foundation of Finnish Diabetes Association
- EU Horizon 2020 [755320, 848146]
- Tampere University Hospital Supporting Foundation
- European Union [305739]
- German Federal Ministry of Education and Research [01EA1411A]
- Pirkanmaa hospital district [9R030, 9S034, 9M053]
- Helmholtz Zentrum Munchen - German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
- State of Bavaria
- Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
- Academy of Finland (AKA) [277079, 328685, 277079, 328685, 335249] Funding Source: Academy of Finland (AKA)
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This study characterized the methylation level of the polymorphically imprinted gene VTRNA2-1/nc886 in human populations and somatic tissues, revealing stable methylation status across populations and somatic tissues with minor variations in specific tissues. The twin data suggested that the imprint of the nc886 gene may be established in the oocyte.
Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas similar to 30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues. Tweetable abstract Methylation status of a polymorphically imprinted gene, VTRNA2-1/nc886, is stable in human populations (48 cohorts, n > 30,000) and in somatic tissues, except in cerebellum and skeletal muscle. Twin data suggest it may already be established in the oocyte.
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