Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 97, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2022.105254
Keywords
Ganoderma lucidum spore; Water extract; Chemical composition; Antioxidant activities; Hypoglycemic activity; Acute liver injury
Categories
Funding
- Jilin Provincial Science and Technology Development Program Project [20210202066NC]
- Opening Project of Engineering Research Center of Edible and Medicinal Fungi (Ministry of Education) , Jilin Agricultural University [JJJW2021001]
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This study identified the chemical composition of sporoderm-broken Ganoderma lucidum spore water extract (BGLWE) and found that it exhibits antioxidant and hypoglycemic activities. BGLWE also showed protective effects against acute liver injury.
This study determined the chemical composition, antioxidant activity, hypoglycemic activity, and acute liver injury-protective effects of sporoderm-broken Ganoderma lucidum spore water extract (BGLWE). A total of 549 substances were identified in BGLWE, among which, the top three identified substances were nicotinamide (9.75 %), gamma-aminobutyric acid (9.44 %), and phytosphingosine (8.36 %). BGLWE exhibited pronounced scav-enging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 '-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and hydroxyl radicals (IC50 of 0.2456, 0.3637, and 3.573 mg/mL, respectively) and also possessed high ferric ion reducing power (absorbance from 0.22 to 3.06). BGLWE showed good inhibitory activities against alpha-amylase and alpha-glucosidase (IC50 of 4.87 and 5.06 mg/mL). In animal experiments, compared with the control CCl4 group, the enzymatic activities of glutathione peroxidase and superoxide dis-mutase of BGLWE were increased by 51.52 % and 41.79 %, respectively, while the malondialdehyde content was decreased by 53.99 %. These results support the use of BGLWE as a natural hypoglycemic and hepatoprotective agent that has potential applications in food and medicine.
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