Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 97, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2022.105249
Keywords
Allergy; Gut microbiome; Asthma; Bifidobacterium; Boswellia serrata
Categories
Funding
- P. L. Thomas Co.Inc [601614-10140-20]
- startup funds for Y.Z. at UConn Health
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This study found that oral supplementation with Boswellia serrata resin has significant effects on allergic pulmonary inflammation and the gut microbiome. Treated mice showed improved lung function and reduced inflammation, while also experiencing an increase in Bifidobacterium in the gut microbiome.
Asthma is associated with significant morbidity. The gut microbiome has been shown to effect asthma devel-opment and exacerbation. In this study, we tested an oral supplement containing Boswellia serrata (Indian frankincense) tree resin on allergic pulmonary inflammation and gut microbiome. An OVA based allergic airway model was used and mice were orally gavaged 100 mg/kg of Boswellia serrata as a supplementation throughout asthma sensitization and challenge. Treated mice showed significant weight loss, lower total lung leukocytes, eosinophil and Th2 cytokines, improved histology scoring and reduced reactivity to methacholine challenge. Asthmatic mice without Boswellia serrata supplementation showed a decrease in overall bacterial diversity, while treated mice were protected against loss. Boswellia serrata treated mice had a significant increase in Bifido-bacterium, which was identified as Bifidobacterium pseudolongum. Oral administration of B. pseudolongum also reduced airway inflammation, suggesting Boswellia serrata may work as an anti-asthma agent via increases in B. pseudolongum from prebiotic influences.
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