Journal
BIOSCIENCE TRENDS
Volume 16, Issue 4, Pages 282-290Publisher
IRCA-BSSA
DOI: 10.5582/bst.2021.01306
Keywords
methylenetetrahydrofolate reductase; IVF; ICSI-ET; folic acid supplementation; active folic acid; 5-MTHF; adverse pregnancy; preterm delivery
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Funding
- Scientific and Technological Innovation Action Plan of the Shanghai Natural Science Fund [20ZR1409100]
- Chinese Association of Integration of Traditional and Western Medicine special foundation for Obstetrics and Gynecology-PuZheng Pharmaceutical Foundation [FCK-PZ-08]
- Shanghai Hospital Association [X2021046]
- clinical trial project of the Special Foundation for Healthcare Research of the Shanghai Municipal Health Commission [202150042]
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This study found an association between MTHFR genetic polymorphism rs1801133 and BMI, but not with pregnancy outcomes. Additionally, MTHFR 677C>T was not associated with preterm delivery. The results suggest that using less expensive and readily available folic acid supplementation may be appropriate in women undergoing IVF/ICSI-ET with adequate synthetic folic acid supplementation.
Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphism rs1801133 (677C 0.001) and BMI (OR = 0.95, 95% CI = 0.90, 0.997, P = 0.037). In 349 clinically pregnant women, no association of the MTHFR 677C T with pregnancy outcomes was found in the additive model, dominant model, or recessive model. Of the 273 women with positive pregnancy outcomes, 34 had a preterm delivery. MTHFR 677C>T was not associated with a preterm delivery after adjusting for age and BMI. The current results indicated that MTHFR polymorphism rs1801133 was not related to the pregnancy rate or pregnancy outcomes of women undergoing IVF/ICSI-ET with adequate synthetic FA supplementation, suggesting that simple supplementation with less expensive and readily available FA, rather than expensive 5-MTHF, appeared to be appropriate.
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