Journal
VIRUSES-BASEL
Volume 14, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/v14112411
Keywords
influenza A virus; nonstructural protein 2; interferon; interferon regulatory factor 7
Categories
Funding
- National Key RD program [2021YFD1800204]
- National Natural Science Foundation of China [32172820, 31961133013, 32272972]
- Chinese Academy of Agricultural Science and Technology Innovation Project [CAAS-ASTIP-JBGS-20210102]
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This study demonstrated a novel mechanism by which the NS2 of H1N1 IAV inhibits IRF7-mediated type-I interferon production.
Influenza A virus (IAV) is a globally distributed zoonotic pathogen and causes a highly infectious respiratory disease with high morbidity and mortality in humans and animals. IAV has evolved various strategies to counteract the innate immune response, using different viral proteins. However, the mechanisms are not fully elucidated. In this study, we demonstrated that the nonstructural protein 2 (NS2) of H1N1 IAV negatively regulate the induction of type-I interferon. Co-immunoprecipitation experiments revealed that NS2 specifically interacts with interferon regulatory factor 7 (IRF7). NS2 blocks the nuclear translocation of IRF7 by inhibiting the formation of IRF7 dimers, thereby prevents the activation of IRF7 and inhibits the production of interferon-beta. Taken together, these findings revealed a novel mechanism by which the NS2 of H1N1 IAV inhibits IRF7-mediated type-I interferon production.
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