A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses

Article Virology

Exploring the tymovirales landscape through metatranscriptomics data

Nicolas Bejerman et al.

Summary: By analyzing plant transcriptome sequences in public databases, 31 novel viral genome sequences associated with Tymovirales were discovered, shedding new light on the classification and evolutionary relationships of these viruses.

ARCHIVES OF VIROLOGY (2022)

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Article Virology

The characterization of multiple novel paramyxoviruses highlights the diverse nature of the subfamily Orthoparamyxovirinae

Bert Vanmechelen et al.

Summary: This study reports the discovery of 15 orthoparamyxoviruses in rodents and shrews from Belgium and Guinea, including 13 new species. Genome analysis revealed the characteristics and differences of these viruses, shedding further light on the complex evolutionary origin and diversity of paramyxoviruses.

VIRUS EVOLUTION (2022)

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Article Genetics & Heredity

A glimpse into the DNA virome of the unique ?living fossil? Welwitschia mirabilis

Humberto Debat et al.

Summary: In this study, four novel DNA viruses were identified and characterized from Welwitschia mirabilis transcriptomic and genomic datasets. These viruses showed affinity to members of the Caulimoviridae and Geminiviridae families, and complete circular virus-like sequences were detected in Welwitschia mirabilis genomic data.

GENE (2022)

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Article Virology

C Protein Is Essential for Canine Distemper Virus Virulence and Pathogenicity in Ferrets

Oliver Siering et al.

Summary: Paramyxoviruses, such as measles virus (MeV) and canine distemper virus (CDV), express accessory proteins like the C protein, which play important roles in regulating the host's immune response and viral replication. MeV C protein prevents excessive production of double-stranded RNA, while a similar disruption in CDV's C open reading frame does not lead to attenuation. By introducing additional mutations to prevent expression of truncated C proteins, a new CDV was successfully attenuated both in cell culture and in ferrets, revealing the crucial role of morbillivirus C proteins in pathogenesis.

JOURNAL OF VIROLOGY (2021)

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Article Virology