The road to the first FDA-approved genetically engineered pig heart transplantation into human

Article Medicine, Research & Experimental

Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months

Muhammad M. Mohiuddin et al.

Summary: This study reports the survival of genetically engineered porcine cardiac xenografts in baboon recipients for almost 9 months. The selective multi-gene modifications significantly improve the survival of cardiac xenografts, offering hope for transplantation in humans.

XENOTRANSPLANTATION (2022)

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Article Medicine, General & Internal

Genetically Modified Porcine-to-Human Cardiac Xenotransplantation

Bartley P. Griffith et al.

Summary: A porcine-to-human heart transplantation was performed on a 57-year-old man with nonischemic cardiomyopathy who was not eligible for standard therapeutics, including traditional allograft. The patient was successfully weaned from ECMO and the xenograft functioned normally until sudden failure on day 49 post-transplantation. Further studies are needed to identify the mechanisms responsible for the changes observed in the xenograft.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Medicine, Research & Experimental

The porcine cytomegalovirus (PCMV) will not stop xenotransplantation

Joachim Denner

XENOTRANSPLANTATION (2022)

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Article Immunology

Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation

Corbin E. Goerlich et al.

Summary: Perioperative cardiac xenograft dysfunction (PCXD) is a rapidly developing loss of cardiac function after xenotransplantation. This study found that using blood cardioplegia induction, alone or followed by XHS perfusion storage, reduced the incidence of PCXD and improved graft function and survival relative to traditional crystalloid cardioplegia-slush storage alone.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cardiac & Cardiovascular Systems