4.3 Review

Updates on eosinophilic disorders

Related references

Note: Only part of the references are listed.
Article Biophysics

Allogeneic hematopoietic cell transplantation in patients with myeloid/lymphoid neoplasm with FGFR1-rearrangement: a study of the Chronic Malignancies Working Party of EBMT

Juan-Carlos Hernandez-Boluda et al.

Summary: Allogeneic hematopoietic cell transplantation shows significant curative potential in patients with FGFR1-rearranged myeloid/lymphoid neoplasm. This study reports on the largest series of FGFR1-rearranged MLN patients undergoing allo-HCT, demonstrating promising overall results in the treatment of this aggressive disease.

BONE MARROW TRANSPLANTATION (2022)

Article Hematology

World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management

William Shomali et al.

Summary: The eosinophilias are a group of diseases that can cause organ damage. Diagnosis relies on various tests, including blood and marrow examination. Prognosis depends on identifying the subtype of eosinophilia. Treatment aims to reduce organ damage and requires individualized therapy.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

Review Oncology

PCM1-JAK2 Fusion Tyrosine Kinase Gene-Related Neoplasia: A Systematic Review of the Clinical Literature

Henry G. Kaplan et al.

Summary: This review summarizes the case studies of PCM1-JAK2 fusion tyrosine kinase gene-related neoplasia, focusing on the clinical course of the disease and the efficacy of treatments used to date.

ONCOLOGIST (2022)

Article Hematology

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Daniel A. Arber et al.

Summary: In 2016, the WHO, Society for Hematopathology, and European Association for Haematopathology collaborated to update the classification of myeloid neoplasms and acute leukemias, advancing the field of myeloid neoplasms and acute leukemias.

BLOOD (2022)

Article Oncology

Partial Response to Sorafenib in a Child With a Myeloid/Lymphoid Neoplasm, Eosinophilia, and a ZMYM2-FLT3 Fusion

Monica C. Munthe-Kaas et al.

Summary: Abnormal tyrosine kinases in myeloid/lymphoid neoplasms with eosinophilia are rare in children, but can be effectively treated with FLT3 tyrosine kinase inhibitors. Despite achieving complete hematologic remission after 17 months of treatment, molecular remission has not been achieved in the presented case.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2021)

Review Pathology

Myeloid/Lymphoid Neoplasms Associated With Eosinophilia and Rearrangements of PDGFRA, PDGFRB, or FGFR1 or With PCM1-JAK2

Olga Pozdnyakova et al.

Summary: This study summarized cases involving myeloidlymphoid neoplasms with eosinophilia and different gene rearrangements, revealing heterogeneous disease presentations and emphasizing the importance of accurate diagnosis and classification for these rare disorders. With advancements in RNA sequencing, cryptic rearrangements and additional somatic mutations were identified, expanding our understanding of these neoplasms and improving our ability to diagnose genetically defined disorders.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2021)

Review Pathology

Eosinophilia/Hypereosinophilia in the Setting of Reactive and Idiopathic Causes, Well-Defined Myeloid or Lymphoid Leukemias, or Germline Disorders Report of the 2019 Society for Hematopathology/European Association for Haematopathology Workshop

Katalin Kelemen et al.

Summary: The 2019 workshop focused on reactive eosinophilia, hypereosinophilic syndrome (HES), germline disorders with eosinophilia (GDE), and myeloid and lymphoid neoplasms associated with eosinophilia. Among 109 cases reviewed, the most frequent diagnosis was reactive eosinophilia, followed by acute leukemia. Myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), and therapy-related myeloid neoplasms were also discussed.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2021)

Article Pathology

Myeloid/lymphoid neoplasms with FLT3 rearrangement

Guilin Tang et al.

Summary: Myeloid/lymphoid neoplasms with FLT3 rearrangement exhibit diverse disease presentations but share common features, including extramedullary involvement, associated eosinophilia, and multilineage involvement. Treatment options such as chemotherapy, FLT3 inhibitors, and hematopoietic stem cell transplant have shown therapeutic benefits for these patients.

MODERN PATHOLOGY (2021)

Review Immunology

Eosinophils and eosinophil-associated disorders: immunological, clinical, and molecular complexity

Peter Valent et al.

Summary: Eosinophils and their mediators play a crucial role in various reactive states. Excessive eosinophils can lead to organ damage. Early therapeutic agents reducing eosinophil counts are effective in preventing irreversible damage.

SEMINARS IN IMMUNOPATHOLOGY (2021)

Article Hematology

Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance

Justin Anthony Chen et al.

Summary: The resistance mechanisms to ruxolitinib in a patient with JAK2-driven hematologic malignancies may involve IKZF1 deletion and an activated B-cell receptor-like signaling phenotype.

BLOOD ADVANCES (2021)

Article Hematology

Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis

Meiyu Chen et al.

Summary: EMS with CEP110-FGFR1 fusion is a rare and aggressive hematologic malignancy characterized by common symptoms such as tonsil hypertrophy, lymphadenopathy, and hepatosplenomegaly. Treatment options include allo-HSCT, with potential therapeutic targets for clinical trials being FGFR1 and RUNX1. High incidence of tonsil hypertrophy and monocytosis may be a feature of EMS with CEP110/FGFR1 fusions.

HEMATOLOGY (2021)

Editorial Material Hematology

Transformation to erythroblastic sarcoma from myeloid neoplasm with PCM1-JAK2

Catherine Luedke et al.

BLOOD (2020)

Article Oncology

Myeloid/lymphoid neoplasms with eosinophilia and FLT3 rearrangement

Haipeng Shao et al.

LEUKEMIA RESEARCH (2020)

Article Oncology

Chronic myelomonocytic leukemia with ETV6-ABL1 rearrangement and SMC1A mutation

Melissa H. Cessna et al.

CANCER GENETICS (2019)

Article Pathology

Hematopoietic neoplasms with 9p24/JAK2 rearrangement: a multicenter study

Guilin Tang et al.

MODERN PATHOLOGY (2019)

Article Oncology

Myeloid/lymphoid neoplasms with FGFR1 rearrangement

Paolo Strati et al.

LEUKEMIA & LYMPHOMA (2018)

Article Hematology

A multimodality work-up of patients with Hypereosinophilia

Zhihong Hu et al.

AMERICAN JOURNAL OF HEMATOLOGY (2018)

Article Medicine, Research & Experimental

Two myeloid leukemia cases with rare FLT3 fusions

Haijiao Zhang et al.

COLD SPRING HARBOR MOLECULAR CASE STUDIES (2018)

Review Hematology

Myeloid neoplasms with eosinophilia

Andreas Reiter et al.

BLOOD (2017)

Review Hematology

Philadelphia chromosome-like acute lymphoblastic leukemia

Sarah K. Tasian et al.

BLOOD (2017)

Letter Hematology

Guideline for the investigation and management of eosinophilia

Nauman M. Butt et al.

BRITISH JOURNAL OF HAEMATOLOGY (2017)

Article Hematology

Characterization of leukemias with ETV6-ABL1 fusion

Marketa Zaliova et al.

HAEMATOLOGICA (2016)

Article Hematology

Characterization of leukemias with ETV6-ABL1 fusion

Marketa Zaliova et al.

HAEMATOLOGICA (2016)

Letter Hematology

Efficacy of ruxolitinib in myeloid neoplasms with PCM1-JAK2 fusion gene

Elisa Rumi et al.

ANNALS OF HEMATOLOGY (2015)

Article Medicine, General & Internal

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

K. G. Roberts et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Allergy

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

Peter Valent et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

Article Hematology

Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia

Thomas Ernst et al.

BRITISH JOURNAL OF HAEMATOLOGY (2011)

Review Hematology

ABL1 fusion genes in hematological malignancies: a review

Etienne De Braekeleer et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2011)

Letter Hematology

ETV6-ABL1-positive chronic myeloid leukemia: clinical and molecular response to tyrosine kinase inhibition

Fabiana Perna et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)

Article Hematology

Molecular characterization of paediatric idiopathic hypereosinophilia

Maria Cristina Rapanotti et al.

BRITISH JOURNAL OF HAEMATOLOGY (2010)

Article Pathology

t(8;13)-positive bilineal lymphomas - Report of 6 cases

Francisco Vega et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2008)

Article Biochemistry & Molecular Biology

A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase

RP Million et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)