4.4 Article

The association between baseline circulating progenitor cells and vascular function: The role of aging and risk factors

Journal

VASCULAR MEDICINE
Volume 27, Issue 6, Pages 532-541

Publisher

SAGE PUBLICATIONS LTD
DOI: 10.1177/1358863X221116411

Keywords

aging; stem cells; vascular biology; pulse wave velocity; microvascular function; reactive hyperemia index (RHI)

Funding

  1. NIH [P01 HL101398, R01 HL109413, R01HL109413-02S1, R01HL125246, K24HL077506, K24 MH076955, UL1TR000454, KL2TR000455, K23HL127251, T32HL130025]

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This study investigates the relationship between vascular function, circulating progenitor cell (CPC) counts, aging, and exposure to risk factors. The findings suggest that a higher CPC count is associated with better vascular function among younger individuals with risk factors, while this association is not observed in older individuals. Additionally, a lower CPC count is an independent predictor of worsening vascular function.
Background: To investigate the cross-sectional and longitudinal relationships between vascular function and circulating progenitor cell (CPC) counts with respect to aging and exposure to risk factors. Methods: In 797 adult participants, CPCs were enumerated by flow cytometry as CD45(med) mononuclear cells expressing CD34 epitope and its subsets co-expressing CD133, and chemokine C-X-C motif receptor 4 (CXCR4+). Arterial stiffness was evaluated by tonometry-derived pulse wave velocity (PWV) and microvascular function was assessed as digital reactive hyperemia index (RHI). Results: In cross-sectional analyses, for every doubling in CD34+ cell counts, PWV was 15% higher and RHI was 9% lower, after adjusting for baseline characteristics and risk factors (p for all < 0.01). There were significant CPC-by-age-by-risk factor interactions (p <0.05) for both vascular measures. Among younger subjects (< 48 years), CPC counts were higher in those with risk factors and vascular function was better in those with higher compared to those with lower CPC counts (p for all < 0.0l). In contrast, in older participants, CPCs were not higher in those with risk factors, and vascular function was worse compared to the younger age group. A lower CPC count at baseline was an independent predictor of worsening vascular function during 2-year follow-up. Conclusion: A higher CPC count in the presence of risk factors is associated with better vascular function among younger individuals. There is no increase in CPC count with risk factors in older individuals who have worse vascular function. Moreover, a higher CPC count is associated with less vascular dysfunction with aging.

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