Odorant receptors as potential drug targets

Odorant receptors (ORs) belong to a large family of G protein-coupled receptors (GPCRs) that are highly expressed by olfactory sensory neurons of the nose. Accumulating evidence indicates that they are also expressed in a variety of nonolfactory tissues, which makes them new potential drug targets. Here we discuss the challenges and strategies to target these receptors.

Automated summary

Odorant receptors (ORs) are G protein-coupled receptors highly expressed in olfactory sensory neurons. Recent evidence suggests they are also expressed in nonolfactory tissues, making them potential drug targets. This article discusses the challenges and strategies in targeting these receptors.