Housebreaking Plasmodium parasites leave their fingerprints at the door

Article Multidisciplinary Sciences

Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria

Fauzia K. Musasia et al.

Summary: The study shows that antibody-dependent phagocytosis of ring-stage P. falciparum parasites in semi-immune Kenyan adults is mediated by merozoite antigens and is a strong predictor of protection.

NATURE COMMUNICATIONS (2022)

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Review Immunology

The challenges of a circumsporozoite protein-based malaria vaccine

Deepyan Chatterjee et al.

Summary: Recent clinical trials have shown that the RTS,S vaccine's protection is incomplete and short-lived, prompting studies to understand why vaccine-induced protection is limited. Research in systems serology has emphasized the importance of inducing functional antibodies, while in-depth analyses of immune responses to CSP have highlighted challenges in generating and maintaining high-quality antibody responses. Biophysical and structural studies of antibody binding to PfCSP have provided insights for future vaccine design to target a broader range of protective targets within PfCSP.

EXPERT REVIEW OF VACCINES (2021)

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Article Medicine, Research & Experimental

Safety and PCR monitoring in 161 semi-immune Kenyan adults following controlled human malaria infection

Melissa C. Kapulu et al.

Summary: The study showed that past exposure to malaria in some Kenyan adults can completely suppress the in vivo growth of a parasite strain originating from outside Kenya.

JCI INSIGHT (2021)

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Review Immunology