COVID-19 mRNA vaccine-induced adverse effects: unwinding the unknowns

We appreciate the efforts of Cosentino and Marino in reviewing and commenting [1] on our recent opinion article on the putative role of the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines-produced antigen - that is, SARS-CoV-2 Wuhan-Hu-1 strain spike (S) protein - in reported adverse effects (AEs) of vaccination [2]. Cosentino and Marino attempted to answer one of our `outstanding questions' ( sixth question in [2]), and they have introduced an additional issue while also providing a plausible answer. We are responding here to the discussion by adding further perspectives to their arguments.

Automated summary

This article is a response to the comments and discussions made by Cosentino and Marino on our opinion article regarding the putative role of SARS-CoV-2 mRNA vaccine-produced antigen in adverse effects of vaccination. They addressed one of our outstanding questions and provided a plausible answer.