Journal
TRENDS IN MICROBIOLOGY
Volume 30, Issue 12, Pages 1131-1134Publisher
CELL PRESS
DOI: 10.1016/j.tim.2022.08.004
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Funding
- NIHR Academic Clinical Lectureship [CL-2019-21-002]
- NIHR Imperial Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London
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Recognition of the microbiome as an emerging hallmark of cancer highlights its potential impact on cancer development and treatment. Microbes can directly cause cancer, influence host immune responses, and affect the efficacy of anticancer therapies. Manipulation of the microbiome holds promise for influencing cancer outcomes.
Recognition of the microbiome (and `polymorphic microbes' within them) as a new emerging hallmark of cancer reflects a wide body of rapidly evolving research. Microbes may be directly carcinogenic, impact host immune responses to promote malignancy, and may be key effectors in determining the efficacy of anticancer therapy. Manipulation of the microbiome is showing promise as an opportunity to influence cancer outcomes.
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