Pin1 and Alzheimer's disease

Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100 years of investigation, the etiology remains elusive and therapy ineffective. Despite current gaps in knowledge, recent studies have identified dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, as an important step in AD pathogenesis. Here I review the functionality of Pin1 and its role in neurodegeneration.

Automated summary

Alzheimer's disease is a significant and escalating public health crisis. Despite extensive research over the past century, its causes remain elusive and current therapies are ineffective. However, recent studies have shed light on the critical role of dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, in the pathogenesis of Alzheimer's disease.