4.7 Review

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples

Related references

Note: Only part of the references are listed.
Article Chemistry, Analytical

Unraveling metabolic alterations in transgenic mouse model of Alzheimer's disease using MALDI MS imaging with 4-aminocinnoline-3-carboxamide matrix

Yanwen Chen et al.

Summary: This study developed a novel MALDI matrix for improved evaluation of metabolic alterations in the brain and serum of an AD mouse model. The research found that 93 metabolites in the brain and 81 metabolites in the serum exhibited changes in AD mice compared to the control group. The application of this method can enhance our understanding of the etiopathogenesis of AD.

ANALYTICA CHIMICA ACTA (2022)

Article Biochemical Research Methods

A Matrix Sublimation Device with an Integrated Solvent Nebulizer for MALDI-MSI

Huizhi Li et al.

Summary: A new integrated matrix deposition device with synchronous solvent nebulization was developed for MALDI-mass spectrometry imaging, improving efficiency and quality in imaging of protein and small metabolite distributions in mouse brain tissue sections. The device demonstrated enhanced sensitivity and image quality compared to conventional methods, showing its utility in MALDI-MSI applications.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2022)

Article Biochemical Research Methods

Spatially resolved isotope tracing reveals tissue metabolic activity

Lin Wang et al.

Summary: Isotope imaging enables quantification of metabolic activity in mammalian tissues with spatial resolution, revealing metabolic heterogeneity in the kidney and brain and spatial gradients in metabolic processes.

NATURE METHODS (2022)

Review Chemistry, Multidisciplinary

Advances in MALDI Mass Spectrometry Imaging Single Cell and Tissues

Xiaoping Zhu et al.

Summary: Compared with conventional optical microscopy techniques, mass spectrometry imaging (MSI) is a powerful label-free analytical technique that can detect, quantify, and map multiple biomolecules in cells and tissues. Matrix-assisted laser desorption/ionization (MALDI) is the most commonly used MSI scanning method.

FRONTIERS IN CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Complex Changes in Membrane Lipids Associated with the Modification of Autophagy in Arabidopsis

Yosia Mugume et al.

Summary: This study investigated the impact of autophagy on plant lipid content and composition using Arabidopsis mutants. The results showed that autophagy affects plant lipid concentrations and properties such as chain length and unsaturation.

METABOLITES (2022)

Article Chemistry, Analytical

6-Glycosylaminoquinoline-assisted LDI MS for detection and imaging of small molecules with enhanced detection selectivity and sensitivity

Ge Ma et al.

Summary: In this study, a matrix glycosylation strategy was proposed to improve the sensitivity and signal reproducibility of MALDI MS analysis. The glycosylated matrices, especially 6-GAQ, exhibited remarkably-improved performance in detecting metabolites and imaging small molecules in complex samples. The glycosylation strategy showed great potential in the field of mass spectrometry.

ANALYTICA CHIMICA ACTA (2022)

Article Chemistry, Analytical

Top-Down Rational Engineering of Heteroatom-Doped Graphene Quantum Dots for Laser Desorption/lonization Mass Spectrometry Detection and Imaging of Small Biomolecules

Zehui Jin et al.

Summary: This study presents a versatile top-down strategy for rational engineering of carbon material-based matrices to assist in the detection and imaging of small biomolecules using MALDI mass spectrometry imaging. Nitrogen-doped graphene quantum dots were found to have superior capability in assisting the detection of various small molecules, and the proposed negative-ion NGQDs-assisted LDI MSI achieved the imaging of low-MW lipids in rat brain tissue. This work offers a new route for customizing nanomaterial matrices and has important applications in biomedical and pathological research.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Analytical

Development of an Automatic Ultrasonic Matrix Sprayer for Matrix-Assisted Laser Desorption/lonization Mass Spectrometry Imaging

Lingwei Meng et al.

Summary: An automatic device called SoniCoat was developed in this study for matrix coating using an ultrasonic nozzle driven by a piezoelectric ceramic. Compared with other commercial and homemade devices, SoniCoat achieved good nebulization effect, generated more homogeneous matrix crystals, and reduced molecular diffusion. Additionally, the newly developed device can be used for in situ derivatization.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Physical

Yolk-shell Ni/NiO anchored on N-doped graphene synthesized as dual-ion MALDI matrix for detecting and imaging bioactive small molecules

Huifang Zhao et al.

Summary: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a powerful tool for analyzing bioactive small molecules. However, background interference from conventional matrices has been a challenge. In this study, a dual-ion MALDI matrix composed of yolk-shell Ni/NiO nanoparticles anchored on nitrogen-doped graphene was developed to enhance MALDI performance. The novel matrix demonstrated superior sensitivity, salt tolerance, and reproducibility compared to traditional matrices. It was successfully applied for the quantitation of blood glucose and qualitative detection of endogenous small molecular metabolites in mice samples. Additionally, the matrix enabled excellent imaging of lipid distribution in the hippocampus region of mice brains, suggesting its potential applications in clinical diagnosis.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Article Biochemical Research Methods

Evaluation of 6 MALDI-Matrices for 10 ?m Lipid Imaging and On-Tissue MSn with AP-MALDI-Orbitrap

Tina B. Angerer et al.

Summary: Mass spectrometry imaging is a technique used to localize and identify lipids in tissue samples. By utilizing an AP-MALDI source coupled to an Orbitrap Elite, lipid locations and structures can be determined with high mass resolution spectra and cellular spatial resolution. Different MALDI matrices and treatment protocols have varying effects on the lipid coverage and signal intensity in positive and negative ion modes.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2022)

Article Environmental Sciences

Spatially revealed perfluorooctane sulfonate-induced nephrotoxicity in mouse kidney using atmospheric pressure MALDI mass spectrometry imaging

Yanyan Chen et al.

Summary: This study used AP-MALDI MSI to reveal the spatial distributions of PFOS in mouse kidneys and its adverse effects on lipid metabolism. PFOS was found to accumulate mainly in the renal pelvis and outer cortex regions, causing damage to the kidneys. Significant down-regulation of certain lipids and up-regulation of others were observed in different regions of the kidneys between control and PFOS-exposed mice.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Review Chemistry, Multidisciplinary

MALDI-MSI Towards Multimodal Imaging: Challenges and Perspectives

Michael Tuck et al.

Summary: Multimodal imaging is a powerful strategy for combining information from multiple images, providing more comprehensive information and better reflecting the nature of tissues. This review focuses on the multimodal approaches of coupling Matrix-assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) with other imaging modalities.

FRONTIERS IN CHEMISTRY (2022)

Article Oncology

MALDI Mass Spectrometry Imaging-Prognostic Pathways and Metabolites for Renal Cell Carcinomas

Franziska Erlmeier et al.

Summary: Renal cell carcinoma (RCC) is a common type of kidney tumor, but prognostic biomarkers for RCC are still lacking. In this study, a large cohort of RCC patients with the three most common RCC subtypes (ccRCC, pRCC, and chRCC) was analyzed using high mass resolution MALDI-MSI for biomarker detection. Several pathways and metabolites with prognostic power for RCC in general and different RCC subtypes were identified.

CANCERS (2022)

Article Chemistry, Analytical

Multicenter Evaluation of Tissue Classification by Matrix-Assisted Laser Desorption/lonization Mass Spectrometry Imaging

Soeren-Oliver Deininger et al.

Summary: This study evaluated the generalization and accuracy of tissue classification based on mass spectrometric imaging across different measurement sites. The results showed that with proper data preprocessing and classification methods, tissue classification based on mass spectrometric imaging is possible and accurate across sites.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Single-Photon-Induced Post-Ionization to Boost Ion Yields in MALDI Mass Spectrometry Imaging

Christoph Bookmeyer et al.

Summary: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a rapidly growing method in the life sciences. The study introduces a novel post-ionization scheme based on single-photon induced chemical ionization using pulsed RF-Kr lamps, which effectively improves the ionization efficiency for analytes. Through the interplay with chemical dopants, the signal of various lipid molecules from mammalian tissue sections was significantly boosted.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Biochemical Research Methods

On-tissue pyrene-1-boronic acid labeling assisted MALDI imaging of catecholamines in porcine adrenal gland

Di Chen et al.

Summary: This study developed a tissue chemical labeling method for visualizing the distribution of three catecholamine compounds in porcine adrenal gland. The on-tissue labeling with pyrene-1-boronic acid greatly improved detection specificity and sensitivity, enabling successful imaging of the compounds. The proposed method offers a robust, easy-to-use, and low-cost approach for simultaneous molecular imaging.

JOURNAL OF CHROMATOGRAPHY A (2022)

Article Multidisciplinary Sciences

Mass spectrometry imaging to explore molecular heterogeneity in cell culture

Tanja Bien et al.

Summary: Molecular analysis on the single-cell level is rapidly growing in the life sciences. This study presents a sensitive approach to single-cell mass spectrometry based on high-resolution imaging and optical microscopy. The multimodal datasets allow for statistical analysis and direct connection of MS data with microscopy information, providing insights into intracellular lipid distributions and subcellular molecular profiles.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Chemistry, Analytical

Developing a Noncontact Heating Matrix Spraying Apparatus with Controllable Matrix Film Formation for MALDI Mass Spectrometry Imaging

Yake Luo et al.

Summary: Matrix deposition is crucial for MALDI-MSI, and a noncontact heating matrix spraying apparatus was developed to control matrix film formation and enhance signal intensity. This apparatus was used to demonstrate the spatial distribution of substances and lipid distribution in brain tissue.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Analytical

Mass spectrometry imaging revealed alterations of lipid metabolites in multicellular tumor spheroids in response to hydroxychloroquine

Yanyan Chen et al.

Summary: In this study, MALDI-MSI was used to analyze A549 lung cancer multicellular spheroids, revealing that HCQ treatment altered the spatial composition and distribution of lipids in the inner and outer regions of the spheroids.

ANALYTICA CHIMICA ACTA (2021)

Article Biochemical Research Methods

Molecular insights into symbiosis-mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation

Tanja Bien et al.

Summary: The Waminoa sp. acoel flatworms hosting Symbiodiniaceae and Amphidinium dinoflagellate algae provide an interesting model for symbiosis in marine environments. Through advanced imaging techniques, it was discovered that different sterol species play specific roles in the metabolism of Waminoa beyond simply serving as a source of energy, highlighting the value of this research for future spatially resolved analysis of sterols.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

Article Biochemical Research Methods

Direct Tissue Mass Spectrometry Imaging by Atmospheric Pressure UV-Laser Desorption Plasma Postionization

Bin Yan et al.

Summary: Matrix-assisted laser desorption ionization at atmospheric pressure is a promising technique for mass spectrometry imaging of biological tissues. Coupling with low-temperature plasma can greatly improve sensitivity. Different methods of applying matrix during MALDI experiments have varying ion yields, with sandwich preparation showing the highest yields. Despite this, matrix-free imaging methods show potential and advancements in postionization strategies are promising for efficient laser sampling under ambient conditions.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

Article Plant Sciences

Unveiling the spatial distribution of aflatoxin B1 and plant defense metabolites in maize using AP-SMALDI mass spectrometry imaging

Laura Righetti et al.

Summary: This study used advanced imaging technology to investigate the response of maize plants to aflatoxin B1, revealing that AFB1 had the most significant impact on anthocyanin biosynthesis and chlorophyll metabolism in roots, while also triggering a series of biochemical responses in above-ground organs.

PLANT JOURNAL (2021)

Article Chemistry, Analytical

Visualization of lipids in cottonseeds by matrix-assisted laser desorption/ionization mass spectrometry imaging

Bingbing Liu et al.

Summary: This study used MALDI-MSI to investigate the spatial distribution of lipids in cottonseeds, revealing heterogeneous distribution patterns of different lipid species within the seeds. The roles of these lipids in metabolic pathways were analyzed, and the relationship between their spatial distribution and functions was studied. The unique distribution patterns of lipid metabolites revealed by MSI may offer new insights into the spatial compartmentation of lipid metabolism in plants and can potentially aid genetic engineering efforts when combined with transcriptomics and proteomics.

TALANTA (2021)

Article Biochemical Research Methods

3D-surface MALDI mass spectrometry imaging for visualising plant defensive cardiac glycosides in Asclepias curassavica

Domenic Dreisbach et al.

Summary: The study utilized 3D-surface MALDI MSI to investigate plant chemical defence in Asclepias curassavica, revealing an accumulation of defence metabolites in damaged leaf tissue. The results highlight the significant potential of this method in plant science, including understanding plant responses to stress and symbiotic relationships.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

Article Chemistry, Analytical

Transmission-Mode MALDI Mass Spectrometry Imaging of Single Cells: Optimizing Sample Preparation Protocols

Tanja Bien et al.

Summary: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has the potential to visualize the spatial distribution of biomolecules in cell cultures and tissue sections with high resolution, but sample preparation is crucial. A study found that a robust sample preparation protocol can preserve cell morphology and molecular integrity, contributing to the study of cell-to-cell heterogeneities at a molecular level. Advancements in single-cell MALDI imaging could benefit from these protocols.

ANALYTICAL CHEMISTRY (2021)

Article Biochemical Research Methods

Factorial Design to Optimize Matrix Spraying Parameters for MALDI Mass Spectrometry Imaging

Caitlin Tressler et al.

Summary: This study optimized matrix spraying parameters for mouse whole kidney lipid imaging using automated pneumatic spraying and a heated sample-holder tray, resulting in improved MALDI imaging performance. The use of sample heating allowed for higher solvent flow rates for better sample extraction, while minimizing analyte delocalization.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

Article Chemistry, Applied

MALDI-TOF/TOF tandem mass spectrometry imaging reveals non-uniform distribution of disaccharide isomers in plant tissues

Lingpeng Zhan et al.

Summary: Mass spectrometry imaging (MSI) is a powerful technique for studying biomolecular locations in tissues, but often struggles to differentiate isomeric compounds. Coupling tandem mass spectrometry with MSI can help differentiate isomers effectively. This study utilized MALDI-TOF/TOF tandem mass spectrometry imaging to successfully differentiate isomeric disaccharides in plant tissues, highlighting the importance of considering isobaric compounds in research.

FOOD CHEMISTRY (2021)

Article Chemistry, Analytical

Visualizing the spatial distribution of endogenous molecules in wolfberry fruit at different development stages by matrix-assisted laser desorption/ ionization mass spectrometry imaging

Wei-Hua Zhao et al.

Summary: This study utilized matrix-assisted laser desorption/ionization mass spectrometry imaging to visualize the spatial distribution changes of important endogenous molecules during wolfberry fruit development. The results showed that different compounds were distributed in different parts of the fruit, providing valuable information for studying the nutritional and physiological roles of plant substances.

TALANTA (2021)

Article Multidisciplinary Sciences

Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques

Yuta Matsuoka et al.

Summary: This study constructed a library of 465 oxPCs using mass spectrometry and found that doubly oxygenated polyunsaturated fatty acid (PUFA)-PCs are generated in the early phase of acetaminophen-induced acute liver failure.

NATURE COMMUNICATIONS (2021)

Article Oncology

Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI

Maria K. Andersen et al.

Summary: This study used mass spectrometry imaging to spatially detect metabolites and lipids in different types of prostate tissues, revealing metabolic differences between cancer, non-cancer epithelium, and stroma. Specific metabolic profiles within prostate cancer samples were identified, highlighting the potential of these metabolites and lipids as diagnostic and prognostic biomarkers, demonstrating the promise of MALDI-TOF MSI as a diagnostic tool for prostate cancer.

CANCER & METABOLISM (2021)

Article Chemistry, Analytical

Development of a Matrix Sublimation Device with Controllable Crystallization Temperature for MALDI Mass Spectrometry Imaging

Hanyi Xie et al.

Summary: The study utilized a homemade matrix sublimation device to achieve uniform distribution and restricted size of matrix crystals on the sample surface, resulting in improved performance and quality of ion images in MALDI mass spectrometry imaging. The sublimator showed good reproducibility in MALDI-MSI experiments of endogenous and exogenous components in strawberry, kidney, and mussel tissues, indicating its potential for high resolution MALDI-MSI applications.

ANALYTICAL CHEMISTRY (2021)

Article Biochemical Research Methods

Venom Gland Mass Spectrometry Imaging of Saw-Scaled Viper, Echis carinatus sochureki, at High Lateral Resolution

Parviz Ghezellou et al.

Summary: The snake venom gland is the site for synthesis, storage, and secretion of venom. While its morphology has been studied, the cellular secretory and functional processes are still not fully understood. Using advanced mass spectrometry imaging techniques, lipids and peptides were identified in the venom gland, providing insights into its composition and potential functions.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

Article Biochemical Research Methods

A Polymer-Based Matrix for Effective SALDI Analysis of Lipids

Jing Yu et al.

Summary: Modified PVDF materials show exciting potential as matrices for SALDI MS acquisition and SALDI imaging, offering excellent performance in lipid analysis.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

Article Chemistry, Analytical

Mass Spectrometry Imaging of Lipids with Isomer Resolution Using High-Pressure Ozone-Induced Dissociation

Britt S. R. Claes et al.

Summary: Conventional MSI technologies face challenges with phospholipid regioisomers, but ozone-induced dissociation (OzID) can help resolve isomeric lipids, enabling imaging and analysis of lipid isomers in tissues.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Analytical

Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Weiwei Tang et al.

Summary: HZN matrix, prepared from alkalizing HZN.HCl with ammonia, shows superior imaging performance for a wide range of endogenous compounds in MALDI MSI, providing higher sensitivity and broader molecular coverage in negative and positive-ion modes.

ANALYTICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography

Benedikt Geier et al.

Summary: We developed a new method CHEMHIST to connect anatomical structure and metabolic function in millimeter-sized symbiotic animals, addressing the limited understanding of metabolic interactions between these animals. By combining MSI and micro-CT, we successfully correlated the distribution of metabolites with the 3D histology of the animals, providing a methodological groundwork for understanding the roles of these symbiotic animals in ecosystem functioning.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Pharmacology & Pharmacy

Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria

Li-Xing Nie et al.

Summary: This study utilized microscopic mass spectrometry imaging to reveal the distribution of phytochemicals in the dried root of Isatis tinctoria, visualizing the locations of some metabolites for the first time. Based on mass spectrometry imaging, samples collected from different habitats were differentiated unambiguously.

FRONTIERS IN PHARMACOLOGY (2021)

Article Endocrinology & Metabolism

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice

Alexandra Aliluev et al.

Summary: This study reveals that an obesogenic diet induces hyperproliferation of intestinal stem cells and progenitors in mice, leading to changes in intestinal cell identities and mucosal changes associated with obesity. The molecular mechanisms linking increased fatty acid synthesis, Ppar signaling, and the Insr-Igf1r-Akt pathway to these changes are described, shedding light on the pathogenesis of metabolic syndrome.

NATURE METABOLISM (2021)

Article Chemistry, Multidisciplinary

Quantification and molecular imaging of fatty acid isomers from complex biological samples by mass spectrometry

Hua Zhang et al.

Summary: This study presents a novel method using PAA-induced epoxidation combined with mass spectrometry to localize the C=C bond in unsaturated fatty acids, allowing for quantification and spatial visualization of FA isomers in biological samples.

CHEMICAL SCIENCE (2021)

Article Chemistry, Analytical

Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue

Maria K. Andersen et al.

ANALYTICAL CHEMISTRY (2020)

Article Microbiology

Spatial metabolomics of in situ host-microbe interactions at the micrometre scale

Benedikt Geier et al.

NATURE MICROBIOLOGY (2020)

Article Chemistry, Multidisciplinary

Gold Nanoparticle-Assisted Black Silicon Substrates for Mass Spectrometry Imaging Applications

Stefania Alexandra Iakab et al.

ACS NANO (2020)

Article Chemistry, Analytical

Toward the Rational Design of Universal Dual Polarity Matrix for MALDI Mass Spectrometry

Penghsuan Huang et al.

ANALYTICAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging

Klara Scupakova et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

An Integrated Microfluidic Probe for Mass Spectrometry Imaging of Biological Samples

Xiangtang Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Biochemical Research Methods

Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds

Reza Shariatgorji et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2020)

Article Biochemical Research Methods

Intracellular Parasites Toxoplasma gondii and Besnoitia besnoiti, Unveiled in Single Host Cells Using AP-SMALDI MS Imaging

Patrik Kadesch et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2020)

Article Multidisciplinary Sciences

Oral squamous cell carcinoma diagnosed from saliva metabolic profiling

Xiaowei Song et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Physics, Atomic, Molecular & Chemical

MALDI-MS imaging of lipids in corn using a flexible ultrasonic spraying device as matrix deposition method

Xing-Li Pei et al.

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY (2020)

Article Biochemical Research Methods

Pneumatically Sprayed Gold Nanoparticles for Mass Spectrometry Imaging of Neurotransmitters

Nolan McLaughlin et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2020)

Article Chemistry, Analytical

Atmospheric Pressure MALDI Mass Spectrometry Imaging Using In-Line Plasma Induced Postionization

Efstathios A. Elia et al.

ANALYTICAL CHEMISTRY (2020)

Article Chemistry, Analytical

3-Aminophthalhydrazide (Luminol) As a Matrix for Dual-Polarity MALDI MS Imaging

Bin Li et al.

ANALYTICAL CHEMISTRY (2019)

Article Biochemical Research Methods

Transmission-mode MALDI-2 mass spectrometry imaging of cells and tissues at subcellular resolution

M. Niehaus et al.

NATURE METHODS (2019)

Article Biochemical Research Methods

Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging

Mohammadreza Shariatgorji et al.

NATURE METHODS (2019)

Article Chemistry, Analytical

Advanced Methods for MALDI-MS Imaging of the Chemical Communication in Microbial Communities

Eike Ulrich Brockmann et al.

ANALYTICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

William J. Perry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Chemistry, Analytical

Matrix Sublimation Device for MALDI Mass Spectrometry Imaging

Roberto Fernandez et al.

ANALYTICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Spatially resolved metabolomics to discover tumor-associated metabolic alterations

Chenglong Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis

Martin R. L. Paine et al.

SCIENTIFIC REPORTS (2019)

Article Medical Laboratory Technology

Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic

Lennart R. S. Huizing et al.

CLINICAL MASS SPECTROMETRY (2019)

Article Chemistry, Multidisciplinary

Fluorinated Gold Nanoparticles for Nanostructure Imaging Mass Spectrometry

Amelia Palermo et al.

ACS NANO (2018)

Article Chemistry, Analytical

Utilizing a Mini-Humidifier To Deposit Matrix for MALDI Imaging

Xi Huang et al.

ANALYTICAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Mass Spectrometry Imaging with Isomeric Resolution Enabled by Ozone-Induced Dissociation

Martin R. L. Paine et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Biochemical Research Methods

AP-MALDI Mass Spectrometry Imaging of Gangliosides Using 2,6-Dihydroxyacetophenone

Shelley N. Jackson et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2018)

Article Biochemical Research Methods

Automated, parallel mass spectrometry imaging and structural identification of lipids

Shane R. Ellis et al.

NATURE METHODS (2018)

Article Plant Sciences

Mass Spectrometry Based Imaging of Labile Glucosides in Plants

Frederik Bogeskov Schmidt et al.

FRONTIERS IN PLANT SCIENCE (2018)

Article Biochemical Research Methods

Sample preparation for mass spectrometry imaging of leaf tissues: a case study on analyte delocalization

Bin Li et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Conjugated Polymers as a New Class of Dual-Mode Matrices for MALDI Mass Spectrometry and Imaging

Kilian Horatz et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Chemistry, Multidisciplinary

High-Spatial Resolution Mass Spectrometry Imaging: Toward Single Cell Metabolomics in Plant Tissues

Rebecca L. Hansen et al.

CHEMICAL RECORD (2018)

Article Biochemical Research Methods

FDR-controlled metabolite annotation for high-resolution imaging mass spectrometry

Andrew Palmer et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

Atmospheric pressure MALDI mass spectrometry imaging of tissues and cells at 1.4-μm lateral resolution

Mario Kompauer et al.

NATURE METHODS (2017)

Article Multidisciplinary Sciences

Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma

Arvin M. Gouw et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemical Research Methods

Recent advancements in matrix-assisted laser desorption/ionization mass spectrometry imaging

Teesha C. Baker et al.

CURRENT OPINION IN BIOTECHNOLOGY (2017)

Article Biochemical Research Methods

Langartech: A Custom-Made MALDI Matrix Sprayer for MALDI Imaging Mass Spectrometry

Ibon Iloro et al.

Article Biochemical Research Methods

Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines

Mohammadreza Shariatgorji et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2015)

Article Multidisciplinary Sciences

Mass spectrometry imaging with laser-induced postionization

Jens Soltwisch et al.

SCIENCE (2015)

Article Biochemical Research Methods

Matrix-assisted laser desorption/ionization mass spectrometry imaging of cardiolipins in rat organ sections

Hay-Yan J. Wang et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2014)

Article Chemistry, Analytical

Comprehensive Imaging of Porcine Adrenal Gland Lipids by MALDI-FTMS Using Quercetin as a Matrix

Xiaodong Wang et al.

ANALYTICAL CHEMISTRY (2014)

Article Biochemical Research Methods

Mass spectrometry imaging of surface lipids on intact Drosophila melanogaster flies

Filip Kaftan et al.

JOURNAL OF MASS SPECTROMETRY (2014)

Article Multidisciplinary Sciences

Alteration of the lipid profile in lymphomas induced by MYC overexpression

Livia S. Eberlin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis

David Calligaris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Chemistry, Analytical

Curcumin: A Multipurpose Matrix for MALDI Mass Spectrometry Imaging Applications

S. Francese et al.

ANALYTICAL CHEMISTRY (2013)

Article Chemistry, Analytical

Hydroxyflavones as a New Family of Matrices for MALDI Tissue Imaging

Xiaodong Wang et al.

ANALYTICAL CHEMISTRY (2013)

Article Chemistry, Analytical

Orbitrap Mass Spectrometry

Roman A. Zubarev et al.

ANALYTICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry: In Situ Molecular Mapping

Peggi M. Angel et al.

BIOCHEMISTRY (2013)

Article Medical Laboratory Technology

A vision for better health: Mass spectrometry imaging for clinical diagnostics

Hui Ye et al.

CLINICA CHIMICA ACTA (2013)

Article Physics, Atomic, Molecular & Chemical

Localisation of adenine nucleotides in heat-stabilised mouse brains using ion mobility enabled MALDI imaging

Eleanor Q. Blatherwick et al.

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY (2013)

Article Biochemistry & Molecular Biology

Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models

Kamila Chughtai et al.

JOURNAL OF LIPID RESEARCH (2013)

Article Biochemical Research Methods

MALDI-mass spectrometry imaging of desalted rat brain sections reveals ischemia-mediated changes of lipids

Hay-Yan J. Wang et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2012)

Article Chemistry, Analytical

MALDI Imaging and Structural Analysis of Rat Brain Lipid Negative Ions with 9-Aminoacridine Matrix

Christopher D. Cerruti et al.

ANALYTICAL CHEMISTRY (2012)

Article Chemistry, Analytical

Single Cell Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Yvonne Schober et al.

ANALYTICAL CHEMISTRY (2012)

Article Biochemical Research Methods

Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS

Andre Zavalin et al.

JOURNAL OF MASS SPECTROMETRY (2012)

Article Chemistry, Analytical

Binary Matrix for MALDI Imaging Mass Spectrometry of Phospholipids in Both Ion Modes

Selina Rahman Shanta et al.

ANALYTICAL CHEMISTRY (2011)

Article Chemistry, Analytical

Stretched Tissue Mounting for MALDI Mass Spectrometry Imaging

Kevin R. Tucker et al.

ANALYTICAL CHEMISTRY (2011)

Article Chemistry, Analytical

Single Hair Cocaine Consumption Monitoring by Mass Spectrometric Imaging

Tiffany Porta et al.

ANALYTICAL CHEMISTRY (2011)

Review Chemistry, Multidisciplinary

MALDI Imaging of Lipid Biochemistry in Tissues by Mass Spectrometry

Karin A. Zemski Berry et al.

CHEMICAL REVIEWS (2011)

Article Chemistry, Analytical

In Situ Primary Metabolites Localization on a Rat Brain Section by Chemical Mass Spectrometry Imaging

Farida Benabdellah et al.

ANALYTICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Nonuniform distribution of glucosinolates in Arabidopsis thaliana leaves has important consequences for plant defense

Rohit Shroff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Chemistry, Analytical

Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry

Dodge L. Baluya et al.

ANALYTICAL CHEMISTRY (2007)

Article Biochemical Research Methods

Sublimation as a method of matrix application for mass spectrometric imaging

Joseph A. Hankin et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2007)

Article Biochemical Research Methods

MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis

Shuichi Shimma et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)

Article Biochemical Research Methods

MALDI tissue imaging: mass spectrometric localization of biomarkers in tissue slices

Martin Schuerenberg et al.

NATURE METHODS (2007)

Article Biochemical Research Methods

Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer

Alexander Makarov et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2006)

Article Chemistry, Analytical

Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer

A Makarov et al.

ANALYTICAL CHEMISTRY (2006)

Article Chemistry, Multidisciplinary

Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry

Justin M. Wiseman et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Article Biochemical Research Methods

9-aminoacridine as a matrix for negative mode matrix-assisted laser desorption/ionization

RL Vermillion-Salsbury et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2002)

Article Chemistry, Analytical

Atmospheric pressure MALDI/ion trap mass spectrometry

VV Laiko et al.

ANALYTICAL CHEMISTRY (2000)

Article Chemistry, Analytical

Atmospheric pressure matrix assisted laser desorption/ionization mass spectrometry

VV Laiko et al.

ANALYTICAL CHEMISTRY (2000)