Recent advances in medicinal chemistry of ampicillin: Derivatives, metal complexes, and sensing approaches

Ampicillin (AMP) is an antibiotic belonging to the b-lactam group, which exhibits a broad spectrum of action in preventing and treatment of various bacterial diseases. The overuse of antibiotics has led to the dissemination of multidrug resistance among pathogenic strains. Thus, many important drugs, including AMP, have lost their biological activity. Currently, the attention of researchers seem to be mostly attracted by the synthesis of new antibiotic drugs, the modification of existing drugs, and the complexation with metal ions, that can improve their biological properties. Moreover, residues of penicillin in food and the environment have received much attention in recent years because of growing concerns regarding food safety and public health. Therefore, the development of novel sensing materials and methods for the detection of antibiotics is also an important topic. This review summarizes recent research trends in the medicinal chemistry of AMP, including its synthesis, rapid and sensitive detection, and metal complexes.(c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

This review summarizes the medicinal chemistry research on Ampicillin, including its synthesis, detection methods, and metal complexes. Current research focuses on the development of new antibiotic drugs and the improvement of existing drugs, as well as the detection of antibiotics.