Journal
TOXICOLOGY
Volume 479, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2022.153306
Keywords
Octocrylene; Mouse oocyte; Meiosis progression; Mitochondrial function
Categories
Funding
- National Natural Science Foundation of China
- project of Shenzhen Sci- ence and Technology Program
- Shenz- hen High-level Hospital Construction Fund
- [31900593]
- [JCYJ20210324105613035]
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This study investigated the impacts of Octocrylene (OCL) on mouse oocyte maturation and quality. The results showed that OCL exposure disrupted oocyte meiotic maturation, reduced oocyte quality, damaged mitochondrial function, and led to overproduction of reactive oxygen species (ROS) and apoptosis.
One of organic ultraviolet (UV) filters, Octocrylene (OCL), is mainly used in various cosmetic products, which is being frequently detected in soil, sediment, aquatic systems and food chain. There is evidence confirmed the reproductive toxicity of OCL in Japanese medaka. However, less was known about the effects of OCL exposure on oocyte quality. Here, we investigated the impacts of OCL on mouse oocyte maturation and quality by exposing oocytes to OCL in vitro at concentrations of 8, 22, 30, 40 and 50 nM. The results showed that OCL markedly reduced mouse oocyte germinal vesicle breakdown (GVBD) at 50 nM and polar body extrusion (PBE) rates at 40 and 50 nM. OCL exposure further disrupted spindle assembly and chromosome alignment, finally inducing aneuploid. Mitochondrial function was also damaged by OCL exposure, leading to ROS overproduction and apoptosis in oocytes. Moreover, OCL treatment impaired the distribution of cortical granules and sperm binding ability of oocytes. In summary, these data demonstrated that OCL could disturb the oocyte meiotic maturation and reduce oocyte quality.
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