4.5 Article

Intramuscular administration of glyoxylate rescues swine from lethal cyanide poisoning and ameliorates the biochemical sequalae of cyanide intoxication

Related references

Note: Only part of the references are listed.
Article Toxicology

Development of sodium tetrathionate as a cyanide and methanethiol antidote

Adriano Chan et al.

Summary: The study shows that sodium tetrathionate can effectively detoxify hydrogen cyanide and has the potential to be an effective antidote against cyanide and methanethiol poisoning.

CLINICAL TOXICOLOGY (2022)

Article Toxicology

Evaluation of aqueous dimethyl trisulfide as an antidote to a highly lethal cyanide poisoning in a large swine model

Tara B. Hendry-Hofer et al.

Summary: The study demonstrated that intramuscular administration of aqueous DMTS improved survival following cyanide poisoning without long-term adverse effects on muscle integrity at the injection site or neurobehavioral outcomes.

CLINICAL TOXICOLOGY (2022)

Article Multidisciplinary Sciences

Glyoxylate protects against cyanide toxicity through metabolic modulation

Jason R. Nielson et al.

Summary: Cyanide acts as a metabolic poison by inhibiting cytochrome c oxidase and other metabolic enzymes, causing metabolic perturbations. Glyoxylate has been identified as a potential cyanide countermeasure that can effectively and rapidly mitigate cyanide toxicity in animal models.

SCIENTIFIC REPORTS (2022)

Review Physiology

Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing?

Andrew P. Holmes et al.

Summary: It is widely recognized that the mitochondria in type I cells of the carotid body (CB) are unique, as they can be inhibited by relatively small decreases in PaO2 compared to other cell types. This characteristic allows the CB to function as an acute oxygen sensor, being stimulated and activating protective reflexes before other cells' metabolism is compromised. However, the exact mechanism of how a decrease in mitochondrial activity leads to depolarization of type I cells is still unclear. This review explores the significance of various signaling pathways in mediating the overall CB response to hypoxia, suggesting that multiple mitochondria-related signaling pathways are likely involved at different oxygen levels (P(a)O(2)s) during hypoxia. Additionally, it remains to be determined whether mitochondrial signaling acts independently or in collaboration with extramitochondrial oxygen sensors.

FRONTIERS IN PHYSIOLOGY (2022)

Article Biotechnology & Applied Microbiology

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

Anupam Patgiri et al.

NATURE BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Cisplatin Analogs Confer Protection against Cyanide Poisoning

Anjali K. Nath et al.

CELL CHEMICAL BIOLOGY (2017)

Article Medicine, Research & Experimental

Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis

W. Taylor Kimberly et al.

JCI INSIGHT (2017)

Article Endocrinology & Metabolism

Glyoxylate, a New Marker Metabolite of Type 2 Diabetes

Victoria J. Nikiforova et al.

JOURNAL OF DIABETES RESEARCH (2014)

Article Gastroenterology & Hepatology

Metabolism of [13C5] hydroxyproline in vitro and in vivo: implications for primary hyperoxaluria

Juquan Jiang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Antidotes for Acute Cyanide Poisoning

Stephen W. Borron et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2012)

Article Pathology

Swine as Models in Biomedical Research and Toxicology Testing

M. M. Swindle et al.

VETERINARY PATHOLOGY (2012)

Review Biochemistry & Molecular Biology

Cysteine/cystine redox signaling in cardiovascular disease

Young-Mi Go et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Endocrinology & Metabolism

Redox compartmentalization and cellular stress

D. P. Jones et al.

DIABETES OBESITY & METABOLISM (2010)

Article Emergency Medicine

CYANIDE POISONING AND CARDIAC DISORDERS: 161 CASES

Jean-Luc Fortin et al.

JOURNAL OF EMERGENCY MEDICINE (2010)

Review Emergency Medicine

Focus on Smoke Inhalation-The Most Common Cause of Acute Cyanide Poisoning

Marc Eckstein et al.

PREHOSPITAL AND DISASTER MEDICINE (2006)

Article Environmental Studies

Incident, accident, catastrophe: Cyanide on the Danube

SA Cunningham

DISASTERS (2005)

Article Urology & Nephrology

Mitochondrial hydroxyproline metabolism: Implications for primary hyperoxaluria

J Knight et al.

AMERICAN JOURNAL OF NEPHROLOGY (2005)

Review Medicine, General & Internal

Current concepts - Acute chemical emergencies

SN Kales et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Cell Biology

Glycolate and glyoxylate metabolism in HepG2 cells

PRS Baker et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)

Review Nutrition & Dietetics

Extracellular thiols and thiol/disulfide redox in metabolism

SE Moriarty-Craige et al.

ANNUAL REVIEW OF NUTRITION (2004)

Article Urology & Nephrology

Control of oxalate formation from L-hydroxyproline in liver mitochondria

T Takayama et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)

Article Biochemistry & Molecular Biology

Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses

DP Jones et al.

FREE RADICAL BIOLOGY AND MEDICINE (2002)