Journal
THROMBOSIS RESEARCH
Volume 231, Issue -, Pages 182-194Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2022.10.001
Keywords
Platelets; Bacteria; Virus; Infection; Immunothrombosis; Neutrophil extracellular traps
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Platelets play a crucial role in immunity and coagulation, able to detect, interact with, and kill pathogens. They induce the formation of microthrombi to prevent pathogen spread and facilitate clearance in the process of immunothrombosis.
Platelets are anucleated cells derived from megakaryocytes that are primarily responsible for hemostasis. However, in recent years, these cytoplasts have become increasingly recognized as immune cells, able to detect, interact with, and kill pathogens. As platelets are involved in both immunity and coagulation, they have a central role in immunothrombosis, a physiological process in which immune cells induce the formation of microthrombi to both prevent the spread of pathogens, and to help facilitate clearance. In this review, we will highlight the role of platelets as key players in the inflammatory and innate immune response against bacterial and viral infection, including direct and indirect interactions with pathogens and other immune cells.
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