Progress towards the syntheses of Bactobolin A and C4-epi-Bactobolin A using a sulfamate-tethered aza-Wacker cyclization strategy

We present a progress report towards Bactobolin A and C4-epi-Bactobolin A. Sulfamate-tethered azaWacker cyclization followed by a Tsuji-Wacker ketone synthesis furnishes a key tricyclic intermediate which we hypothesize can be elaborated into C4- epi-Bactobolin A. Epimerization of one of the stereocenters of this compound furnishes an intermediate which we hypothesize can be elaborated into Bactobolin A. (c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

This progress report presents the research towards Bactobolin A and C4-epi-Bactobolin A. Key intermediates were synthesized through specific chemical reactions, which can be further elaborated into the desired compounds.