Journal
TALANTA
Volume 247, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2022.123593
Keywords
Pechini modified method; Tb2Ti2O7 nanostructures; Anti-inflammatory drug analysis; Mefenamic acid
Categories
Funding
- council of Iran National Science Foundation
- INSF [97017837]
- University of Kashan [159271/MV2]
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This paper investigates the electrochemical determination of mefenamic acid (MEF) in biological samples using a novel carbon paste electrode modified with terbium titanate nanostructures (TTN/CPE). The study demonstrates that the suggested sensor, with optimized conditions, shows good sensitivity, selectivity, stability, and reproducibility for detecting MEF, making it suitable for important biological samples and wastewater with satisfactory results.
Today, in most fields, wide research has been done in the manufacture of biosensors and the detection of various types of substances, including drugs. Nevertheless, the analytical detection of drugs from a biological sample by a simple and portable method for on-site detection is still important and very challenging. This paper investigates the electrochemical determination of the mefenamic acid (MEF), with a novel carbon paste electrode modified with terbium titanate nanostructures (TTN/CPE). The effect of the capping agent on the morphology and size of terbium titanate synthesized from terbium nitrate in the presence of ethylene glycol (EG) as a stabilization agent is investigated. The as-produced nanostructures are characterized by X-ray diffraction (XRD), Fourier transforms infrared (FT-IR) spectroscopy, energy dispersive X-ray microanalysis (EDX), scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HR-TEM). Electrochemical studies in optimized conditions indicate MEF has two linear responses in the range of 1.0 x 10(-2)-4.0 x 10(2) mu M with a detection limit of 2.4 nM at the surface of TTN/CPE. The suggested sensor reveals good sensitivity, selectivity, stability, and reproducibility and can be utilized for some important biological samples and wastewater with satisfactory results.
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