Journal
TALANTA
Volume 247, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2022.123610
Keywords
Sulfanilamide; Antibiotic; Breast milk; Additive manufacturing; 3D-pen; Carbon black; polylactic acid filament
Categories
Funding
- FAPEMIG (Research Support Foundation of the State of Minas Gerais) [APQ00042-2021]
- CNPq (National Council for Scientific and Technological Development) [302685/2019-7, 163330/2020-4]
- CAPES (Coordination for the Improvement of Higher Education Personnel) [001]
- PROPESQ/UFJF
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This paper presents a simple and cost-effective method for manufacturing a 3D-printed electrode and demonstrates its application in sulfanilamide determination. The 3D-printed electrode shows excellent analytical performance and selectivity, making it suitable for the analysis of various samples such as breast milk, synthetic urine, and otologic solution.
This paper describes a simple and cost-effective method for manufacturing a 3D-printed electrode. This electrode presented a similar design to commercial electrodes, where a stereolithography printer was used to build the electrode body using an acrylic resin. The electroactive surface was filled by a 3D-pen using a carbon black integrated polylactic acid (CB/PLA) conductive filament. After a simple and fast (400 s) surface treatment, the 3D-printed CB/PLA electrode was combined with Differential Pulse Voltammetry (DPV) technique for sulfanilamide (SAA) determination. The developed electroanalytical method was applied to breast milk, synthetic urine, and otologic solution samples, showing excellent analytical performance with a detection limit of 12 nmol L-1, wide linear range from 1 to 39.2 mu mol L-1, and good precision (RSD = 1.8%, n = 10). In addition, the sensor provides fantastic selectivity towards other antibiotic classes, and when applied in spiked samples, recovery values between 93 and 108% were obtained, which demonstrated good accuracy as well as the absence of matrix effect. It is highlighted that no laborious sample preparation steps were required (simple dilution in supporting electrolyte). Thus, the proposed 3D-printed device proves to be a promising analytical tool for routine analysis.
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