4.3 Article

Palladium(II)-catalyzed tandem reaction for the assembly of 1,3-disubstituted pyrrolo[1,2-α]pyrazines

Journal

SYNTHETIC COMMUNICATIONS
Volume 52, Issue 18, Pages 1788-1795

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2022.2112605

Keywords

pyrrolo[1, 2-alpha]pyrazine; C-C coupling; palladium; cascade reaction

Funding

  1. Zhejiang Provincial Public Welfare Projects [LGF22H300002]
  2. Jinhua Science and Technology Projects [2021-3-005]

Ask authors/readers for more resources

An efficient and simple method for the synthesis of 1, 3-disubstituted pyrrolo[1, 2-alpha]pyrazines has been developed. It involves a palladium(II)-catalyzed cascade reaction that includes C(sp)-C(sp(2)) coupling followed by intramolecular C-N bond formation. The method can tolerate various substrates and provides satisfactory yields.
An efficient and simple synthesis of 1, 3-disubstituted pyrrolo[1, 2-alpha]pyrazines from substituted 1H-pyrrole- 2-carbonitriles and arylboronic acids was developed. It's a palladium(II)-catalyzed cascade reaction involving C(sp)-C(sp(2)) coupling followed by intramolecular C-N bond formation. The method can tolerate various substrates with satisfactory yields.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available