Journal
SYNTHESIS-STUTTGART
Volume 55, Issue 4, Pages 663-669Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1947-6049
Keywords
synthetic study; vetiverianine A; 5-epi-vetiverianine A; oxidative cyclization; Rh-catalyzed coupling
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In this article, the synthesis of (+/-)-5-epi-vetiverianine A is reported. Key reactions including a rhodium-catalyzed coupling reaction and an oxidative phenolic cyclization enable efficient and stereoselective access to (+/-)-5-epi-vetiverianine A in 11 steps, with an overall yield of 20%. The stereochemistry is confirmed through NOE studies.
In this article, we report the synthesis of (+/-)-5-epi-vetiverianine A. The key reactions, including a rhodium-catalyzed coupling reaction and an oxidative phenolic cyclization, allow for efficient and stereoselective access to (+/-)-5-epi-vetiverianine A in 11 steps, and in 20% overall yield. The stereochemistry is confirmed by NOE studies.
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