Preparation of 4-Arylthiazol-2(3H)-ones and the Three-Component Synthesis of Multidentate 5,5′-Methylenebis[4-arylthiazol-2(3H)one] Ligands

The synthesis of 4-arylthiazol-2(3H)-ones is reported employing a novel and mild methodology using benign solvents. In a second objective, the multicomponent preparation of 5,5'-methylenebis[4-arylthiazol-2(3H)-ones] is described following the same strategy. The analysis of the mechanism is also studied and confirmed using chemical tests.

Automated summary

A new and mild methodology using benign solvents is reported for the synthesis of 4-arylthiazol-2(3H)-ones. Additionally, the multicomponent preparation of 5,5'-methylenebis[4-arylthiazol-2(3H)-ones] is described using the same strategy. The mechanism is analyzed and confirmed through chemical tests.