4.5 Article

miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1

Related references

Note: Only part of the references are listed.
Review Cell Biology

Mitophagy in degenerative joint diseases

Kai Sun et al.

Summary: Mitochondrial dysfunction is crucial in the development of intervertebral disc degeneration and osteoarthritis. Targeting mitophagy pathways may offer promising therapeutic strategies for degenerative joint diseases.

AUTOPHAGY (2021)

Article Cell Biology

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

Run-Ze Yang et al.

Summary: The study demonstrates the involvement of ferroptosis in the pathogenesis of intervertebral disc degeneration (IVDD) by detecting changes in protein levels and lipid peroxidation during oxidative stress. Treatment with ferroptosis inhibitors and ferritinophagy supports the role of ferroptosis in IVDD.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Medicine, Research & Experimental

miR-4478 sensitizes ovarian cancer cells to irradiation by inhibiting Fus and attenuating autophagy

Lingling Wang et al.

Summary: Ovarian cancer is a common and highly lethal cancer, with radioresistance being a major cause of relapse. The study revealed that miR-4478 enhances the sensitivity of OC cells to radiation by targeting and inhibiting Fus.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Cell Biology

SIRT3 mitigates intervertebral disc degeneration by delaying oxidative stress-induced senescence of nucleus pulposus cells

Jiayi Lin et al.

Summary: The study showed that SIRT3 can delay NPC senescence, reducing oxidative stress and mitigating intervertebral disc degeneration. The activation of the AMPK/PGC-1 alpha pathway partially regulates the effects of SIRT3, indicating a potential therapeutic target for IVDD.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Rheumatology

Cell-based strategies for IVD repair: clinical progress and translational obstacles

Abbie L. A. Binch et al.

Summary: Intervertebral disc degeneration is a common cause of low back pain, with current lack of approved pharmacological interventions to prevent its progression. Cell-based therapies are emerging as promising approaches for repairing the degenerated discs, but face various challenges in terms of understanding disease mechanisms, standardizing preclinical testing, and defining guidelines for clinical trials.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Medicine, Research & Experimental

被撤回的出版物: MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21 (Retracted article. See vol. 28, pg. 534, 2022)

Yiqiang Sun et al.

Summary: The study revealed that miR-199a-5p promotes nucleus pulposus cell apoptosis and IVDD progression by inhibiting SIRT1-dependent deacetylation of p21.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Immunology

Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis

Xinpeng Zhou et al.

Summary: The study found that LLDT-8 inhibited the proliferation, invasion, and cytokine production of RA FLS by regulating the WAKMAR2/miR-4478/E2F1/p53 axis.

FRONTIERS IN IMMUNOLOGY (2021)

Article Chemistry, Medicinal

Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration

Huihao Zhang et al.

Summary: Through network pharmacology analysis, the key targets and pathways of LWDHD in treating IVDD were verified, with animal experiments showing that LWDHD not only restored the disc height reduction and abnormal matrix metabolism degradation in IVDD mice, but also inhibited apoptosis and ameliorated the progression of IVDD.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Cell & Tissue Engineering

Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration

Yongjin Sun et al.

Summary: iMSC-sEVs could delay the progression of intervertebral disc degeneration and rejuvenate senescent nucleus pulposus cells (NPCs) by activating the Sirt6 pathway. Moreover, miR-105-5p enriched in iMSC-sEVs plays a crucial role in the therapeutic effect by downregulating PDE4D and leading to Sirt6 activation.

STEM CELL RESEARCH & THERAPY (2021)

Review Medicine, General & Internal

Low back pain

Nebojsa Nick Knezevic et al.

Summary: Low back pain encompasses various types of pain, with diagnostic and therapeutic methods controversial, requiring a comprehensive approach considering biological, psychological, and social factors. Improvement in diagnostic accuracy, treatment algorithms, and multimodal interdisciplinary treatment are essential.

LANCET (2021)

Article Medicine, Research & Experimental

被撤回的出版物: Role of microRNA-15a-5p/Sox9/NF-κB axis in inflammatory factors and apoptosis of murine nucleus pulposus cells in intervertebral disc degeneration (Retracted article. See vol. 325, 2023)

Shujun Zhang et al.

Summary: The study revealed that in IVDD, miR-15a-5p expression increased while Sox9 expression decreased. Down-regulation of miR-15a-5p could elevate Sox9 through the NF-kappa B pathway, suppressing inflammatory responses and apoptosis of NPCs in IVDD mice, promoting NPC proliferation, and arresting NPCs in S and G2/M phases.

LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro

Xiaoqiang Cheng et al.

Summary: The study demonstrated that CB2 activation can inhibit oxidative stress and inflammatory response in rat NPCs induced by H2O2, as well as effectively delay the development of IVDD, providing a potential therapeutic target for the disease.

MOLECULAR MEDICINE (2021)

Article Cell Biology

HIF-1α-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP

Xiaogang Bao et al.

Summary: miR-623 is downregulated in IVDD and regulated by HIF-1 alpha under oxidative stress conditions, functioning as an intermediator in alleviating apoptosis and inflammatory responses of NP cells.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Chemistry, Medicinal

Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation

Julie Farand et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

Review Cell Biology

Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

Sidong Yang et al.

AGEING RESEARCH REVIEWS (2020)

Article Endocrinology & Metabolism

Mechanics and Biology Interact in Intervertebral Disc Degeneration: A Novel Composite Mouse Model

Zhi-feng Xiao et al.

CALCIFIED TISSUE INTERNATIONAL (2020)

Article Medicine, General & Internal

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

Brice Moukengue et al.

EBIOMEDICINE (2020)

Review Pharmacology & Pharmacy

Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives

Yizhen Yin et al.

ACTA PHARMACEUTICA SINICA B (2020)

Article Medicine, Research & Experimental

MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage

Sophia F. Magkouta et al.

JCI INSIGHT (2020)

Article Cell Biology

Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis

Jingwei Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Medicine, Research & Experimental

MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

Lin Xie et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Biochemistry & Molecular Biology

Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4

Xuyang Zhang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Article Medicine, Research & Experimental

MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4

Jing-chuan Sun et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Cell Biology

Potent and specific MTH1 inhibitors targeting gastric cancer

Wenjuan Zhou et al.

CELL DEATH & DISEASE (2019)

Article Orthopedics

Histological and reference system for the analysis of mouse intervertebral disc

Vivian Tam et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2018)

Article Medicine, General & Internal

What low back pain is and why we need to pay attention

Jan Hartvigsen et al.

LANCET (2018)

Article Medicine, Research & Experimental

Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells

Ruijun He et al.

LIFE SCIENCES (2018)

Article Multidisciplinary Sciences

miRWalk: An online resource for prediction of microRNA binding sites

Carsten Sticht et al.

PLOS ONE (2018)

Article Multidisciplinary Sciences

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Ming-liang Ji et al.

NATURE COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Yusaku Nakabeppu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Orthopedics

Role of miR-155 in the Regulation of MMP-16 Expression in Intervertebral Disc Degeneration

Wei-Lin Zhang et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

Article Biotechnology & Applied Microbiology

MicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis

Jun Lu et al.

MOLECULAR THERAPY (2017)

Editorial Material Medicine, General & Internal

Management of Sciatica

Ramya Ramaswami et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Oncology

MTH1 as a Chemotherapeutic Target: The Elephant in the Room

Govindi J. Samaranayake et al.

CANCERS (2017)

Article Genetics & Heredity

Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14

Ming-liang Ji et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

Article Oncology

Validation and development of MTH1 inhibitors for treatment of cancer

U. Warpman Berglund et al.

ANNALS OF ONCOLOGY (2016)

Article Medicine, General & Internal

Herniated Lumbar Intervertebral Disk

Richard A. Deyo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Biochemistry & Molecular Biology

Free radicals, reactive oxygen species, oxidative stress and its classification

Volodymyr I. Lushchak

CHEMICO-BIOLOGICAL INTERACTIONS (2014)

Article Multidisciplinary Sciences

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad et al.

NATURE (2014)

Review Rheumatology

Role of cytokines in intervertebral disc degeneration: pain and disc content

Makarand V. Risbud et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

Article Biochemistry & Molecular Biology

Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION

Hua Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

Bogdan Mateescu et al.

NATURE MEDICINE (2011)

Review Biochemistry & Molecular Biology

Reactive oxygen species in cancer

Geou-Yarh Liou et al.

FREE RADICAL RESEARCH (2010)

Review Biochemistry & Molecular Biology

MicroRNAs: Target Recognition and Regulatory Functions

David P. Bartel