Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 278, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2022.121326
Keywords
Hyperuricemia; Uric acid; Tears; Inverse opal structure; Surface-enhanced Raman scattering
Categories
Funding
- National Natural Science Foun-dation of China [51973017, 51773017, 81700799, 82070926]
- State Key Laboratory for Advanced Metals and Materials [2018Z-06]
- Fundamental Research Funds for the Central Universi-ties [FRF-DF-19-001]
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Hyperuricemia, closely related to various diseases, has been identified as one of the most persistent diseases in the 21st century. To address this issue, we developed ordered inverse opal array structures (PAANs) for the detection of uric acid in tears of hyperuricemia patients, demonstrating its rapid, effective, and non-invasive nature.
Hyperuricemia is closely related to a variety of diseases and has been listed as one of the twenty most persistent diseases in the 21st century by the United Nations. Therefore, strengthening the diagnosis of hyperuricemia has become imperative. Here, ordered inverse opal array structures (PAANs) composed of PDMS and gold nanoparticles (AuNPs) have been designed using a bottom-up self-assembly method. The structures exhibit a periodic distribution of hot spots, an enhancement factor (EF) of 4.22 x 10(4), and a relative standard deviation (RSD) of signal intensity of less than 5%, which can provide high reproducibil-ity of SERS signals. The PAANs substrate is used to detect uric acid in the tears of patients with hyper-uricemia, and the limit of detection is 6.03 lM. The significant linear relationship between blood uric acid and tear uric acid indicates that the developed method is a rapid, effective, and non-invasive tech-nique for the determination of uric acid in tears. (c) 2022 Elsevier B.V. All rights reserved.
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