Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 279, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2022.121364
Keywords
Fluorescent probe; Indanone-based; Cysteine; Homocysteine; Intramolecular charge transfer
Categories
Funding
- National Natural Science of China
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A novel fluorescent probe based on indanone was developed for effective detection of Cys and Hcy. The probe showed weak fluorescence but exhibited obvious enhancement when reacted with Cys/Hcy. It demonstrated good anti-interference and low cytotoxicity, making it suitable for monitoring Cys and Hcy in living cells.
Effective detection of Cys and Hcy plays an important role in the diagnosis of diseases. In this work, a novel indanone-based fluorescent probe INIAc-CN for sensitively and effectively detecting Cys and Hcy was developed. The probe exhibited weak fluorescence, but obvious fluorescent enhancement after reacted with Cys/Hcy. Moreover, the good anti-interference and low cytotoxicity of the probe made it successfully applied for monitoring Cys and Hcy of in living cells.CO 2022 Elsevier B.V. All rights reserved.
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