4.8 Article

Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy

Journal

SMALL
Volume 18, Issue 41, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202202161

Keywords

catalytic therapy; ferroptosis; nanozymes; photothermal therapy

Funding

  1. National Key Research and Development Program of China [2020YFA0908000]
  2. Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine [ZYYCXTD-C-202002]
  3. Basic and Applied Basic Research Foundation of Guang Dong Province [2021A1515012164]
  4. International Science and Technology Cooperation for Shenzhen Technology Innovation Plan [GJHZ20200731095411034]
  5. CACMS Innovation Fund [CI2021A05101, CI2021A05104]

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This study develops a nanosystem based on the tumor microenvironment to achieve tumor control through simultaneous induction of ferroptosis and apoptosis. The synergistic strategy increases the production of intracellular lipid-reactive oxygen species, leading to complete eradication of tumors.
It is highly desirable to design a single modality that can simultaneously trigger apoptosis and ferroptosis to efficiently eliminate tumor progression. Herein, a nanosystem based on the intrinsic properties of tumor microenvironment (TME) is designed to achieve tumor control through the simultaneous induction of ferroptosis and apoptosis. CuCP molecules are encapsulated in a liposome-based nanosystem to assemble into biocompatible and stable CuCP nanoparticles (CuCP Lipo NPs). This nanosystem intrinsically possesses nanozymatic activity and photothermal characteristics due to the property of Cu atoms and the structure of CuCP Lipo NPs. It is demonstrated that the synergistic strategy increases the intracellular lipid-reactive oxides species, induces the occurrence of ferroptosis and apoptosis, and completely eradicates the tumors in vivo. Proteomics analysis further discloses the key involved proteins (including Tp53, HMOX1, Ptgs2, Tfrc, Slc11a2, Mgst2, Sod1, and several GST family members) and pathways (including apoptosis, ferroptosis, and ROS synthesis). Conclusively, this work develops a strategy based on one nanosystem to synergistically induce ferroptosis and apoptosis in vivo for tumor suppression, which holds great potential in the clinical translation for tumor therapy.

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