4.7 Article

A novel electrochemical aptasensor based on Ti3C2-MOFs nanocomposites for rapid streptomycin detection in milk samples

Journal

SENSORS AND ACTUATORS B-CHEMICAL
Volume 368, Issue -, Pages -

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2022.132119

Keywords

Electrochemical sensing; Aptasensor; Ti3C2; Metal organic frameworks; Streptomycin

Funding

  1. Key Industry Innovation Chain Project of Key Research and Development Program in Shaanxi Province [2019ZDLNY06-06]
  2. Science and Technology Program of Xi?an City [20NYYF0018]
  3. Fundamental Research Funds for the Central Uni-versities [2020CSLY015]
  4. Project of Cooperating to Build Jin-chang Meat Sheep Experimental Demonstration Base [A289021806, K3320219064]

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In this study, an electrochemical aptasensor based on two-dimensional titanium carbide and metal-organic frameworks nanomaterials was developed for the rapid detection of streptomycin residue in milk samples. The aptasensor exhibited wide detection range, low limit of detection, excellent reproducibility, stability, and selectivity. The proposed method provides a new and effective approach for the rapid detection of streptomycin and a sensing platform for the detection of other toxins.
Streptomycin (STR) residue excess in animal-derived foods can cause severe side-effects, such as ototoxicity and nephrotoxicity. Herein, a novel electrochemical aptasensor based on Ti3C2 and metal-organic frameworks (MOFs) nanomaterials was developed for the rapid detection of STR in milk samples. The nanocomposites were synthesized using an impregnation method, and their morphology and structure were characterized via several characterization methods. The nanocomposites exhibited excellent electrochemical properties. Under the optimal conditions, the aptasensor offered a wide STR detection range from 0.01 to 200 nM with a lower limit of detection of 0.0033 nM. Furthermore, the aptasensor demonstrated remarkable reproducibility, stability, and selectivity and was successfully applied for the STR detection in milk samples with satisfactory recoveries ranging from 94.0% to 105.0%. The proposed method can be considered a new and effective method for the rapid detection of STR. Moreover, it provides a new sensing platform for the detection of other toxins.

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