Journal
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
Volume 96, Issue 8, Pages 1687-1692Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0036024422080088
Keywords
metal-organic framework; cyclodextrin; niflumic acid; encapsulation; complexation
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Funding
- Ivanovo State University [60-21G]
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A metal-organic framework based on gamma-cyclodextrin and K+ cations is proposed as a delivery system for niflumic acid, and its effects on the release kinetics and membrane permeability of niflumic acid are investigated.
A metal-organic framework based on gamma-cyclodextrin and K+ cations synthesized by antisolvent vapor diffusion method is proposed as a delivery system for niflumic acid, a non-steroidal anti-inflammatory agent with limited aqueous solubility. Methods of loading niflumic acid into the framework are discussed. The resulting composites are characterized via XRD, low-temperature nitrogen sorption/desorption, and IR spectroscopy. Encapsulation in a metal-organic framework has effect on the kinetics of niflumic acid release and its membrane permeability.
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