Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 44, Issue 2, Pages 426-432Publisher
WILEY
DOI: 10.1002/jmri.25144
Keywords
multiple sclerosis; quantitative susceptibility mapping (QSM); longitudinal change; magnetic resonance imaging; gadolinium enhancement
Funding
- U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke [NS090464]
- U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering [EB13443]
- National Natural Science Foundation of China [81401390]
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PurposeTo measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). Materials and MethodsThe study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. ResultsLesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.616.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 +/- 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001). ConclusionMS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.
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