4.2 Article

Drug resistance in NSCLC is associated with tumor micro-environment

Related references

Note: Only part of the references are listed.
Article Oncology

Tumour microenvironment (TME) characterization identified prognosis and immunotherapy response in muscle-invasive bladder cancer (MIBC)

Rui Cao et al.

Summary: The study characterized the TME pattern in MIBC using the ESTIMATE algorithm and established the TMERS signature, which showed strong correlation with immune infiltration and expression of immune checkpoints. TMERS was negatively correlated with TMB, and combining the two markers improved prediction of ICI response.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Multidisciplinary Sciences

Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Alexandre F. Aissa et al.

Summary: Tyrosine kinase inhibitors have clinical effectiveness in treating certain subsets of cancers with receptor tyrosine kinase somatic mutations, but limited duration of response and development of drug resistance are common issues. Single-cell RNA sequencing revealed multiple cancer cell subpopulations with epigenetic changes and variable therapeutic sensitivity. Overrepresented gene ontologies associated with drug tolerance include epithelial-to-mesenchymal transition, drug metabolism, and vesicle transport. Combination therapy targeting specific drug tolerant cell subpopulations shows promise in inhibiting drug resistance.

NATURE COMMUNICATIONS (2021)

Review Oncology

Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer

Peter T. Harrison et al.

SEMINARS IN CANCER BIOLOGY (2020)

Article Multidisciplinary Sciences

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira A. Barkal et al.

NATURE (2019)

Review Immunology

The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer

Nadege Bercovici et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Oncology

Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors

Satya Das et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Biochemistry & Molecular Biology

Identifying cell populations with scRNASeq

Tallulah S. Andrews et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Review Biochemistry & Molecular Biology

Ovarian cancer stem cells: still an elusive entity?

Michela Lupia et al.

MOLECULAR CANCER (2017)

Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

Review Oncology

Understanding and targeting resistance mechanisms in NSCLC

Julia Rotow et al.

NATURE REVIEWS CANCER (2017)

Review Immunology

CTLA-4 blockade in the treatment of rheumatoid arthritis: an update

Maurizio Cutolo et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Therapy-induced tumour secretomes promote resistance and tumour progression

Anna C. Obenauf et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

The prognostic landscape of genes and infiltrating immune cells across human cancers

Andrew J. Gentles et al.

NATURE MEDICINE (2015)

Review Biochemistry & Molecular Biology

Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer

Matthew J. Niederst et al.

SCIENCE SIGNALING (2013)

Article Multidisciplinary Sciences

Inferring tumour purity and stromal and immune cell admixture from expression data

Kosuke Yoshihara et al.

NATURE COMMUNICATIONS (2013)

Review Oncology

Cancer drug resistance: an evolving paradigm

Caitriona Holohan et al.

NATURE REVIEWS CANCER (2013)

Article Oncology

Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer

Adam D. Steg et al.

CLINICAL CANCER RESEARCH (2012)

Review Biochemistry & Molecular Biology

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kai Kessenbrock et al.

Article Biochemical Research Methods

mRNA-Seq whole-transcriptome analysis of a single cell

Fuchou Tang et al.

NATURE METHODS (2009)

Article Medicine, General & Internal

Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer.

Rafael Rosell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Medicine, General & Internal

Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma.

Tony S. Mok et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Multidisciplinary Sciences

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

Guo-Yun Chen et al.

SCIENCE (2009)

Article Mathematical & Computational Biology

Measures to assess the prognostic ability of the stratified Cox proportional hazards model

J. Danesh et al.

STATISTICS IN MEDICINE (2009)

Article Biology

Adaptive lasso for Cox's proportional hazards model

Hao Helen Zhang et al.

BIOMETRIKA (2007)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Medicine, General & Internal

Erlotinib in previously treated non-small-cell lung cancer

FA Shepherd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)