4.5 Review

Immunomodulation for unexplained recurrent implantation failure: where are we now?

Related references

Note: Only part of the references are listed.
Article Obstetrics & Gynecology

Low-dose aspirin treatment improves endometrial receptivity in the midluteal phase in unexplained recurrent implantation failure

Xiaoxin Zhang et al.

Summary: The study found that URIF patients had significantly higher endometrial blood flow parameters, while the differences in endometrial thickness and uterine perfusion impedance were not significant. Treatment with low-dose aspirin can improve endometrial receptivity in URIF patients.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2022)

Article Endocrinology & Metabolism

Effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: a randomized controlled trial

Marzieh Zamaniyan et al.

Summary: The study showed that intrauterine infusion of platelet-rich plasma 48 hours before freeze-thawed embryo transfer may lead to higher clinical pregnancy and ongoing pregnancy rates in recurrent implantation failure patients. This method could be more effective in in vitro fertilization (IVF) outcomes.

GYNECOLOGICAL ENDOCRINOLOGY (2021)

Review Reproductive Biology

In vitro models of the human endometrium: evolution and application for women's health

Harriet C. Fitzgerald et al.

Summary: The endometrium plays a crucial role in embryo implantation and pregnancy establishment, but research on the human endometrium is incomplete due to ethical and practical limitations. Therefore, the development of in vitro models of the human endometrium is necessary to fill significant gaps in understanding its biology.

BIOLOGY OF REPRODUCTION (2021)

Article Obstetrics & Gynecology

Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers

Paul Pirtea et al.

Summary: The study retrospectively analyzed data from 4,429 women and found that the true recurrent implantation failure rate is low. For patients capable of producing euploid blastocysts, transferring three embryos can still achieve a high clinical pregnancy rate.

FERTILITY AND STERILITY (2021)

Review Obstetrics & Gynecology

A review of the pathophysiology of recurrent implantation failure

Jason M. Franasiak et al.

Summary: Implantation is a critical step in human reproduction, and recurrent implantation failure can result from various factors. Literature discussing this clinical phenomenon is increasing, and there is not a universally agreed-on definition for it.

FERTILITY AND STERILITY (2021)

Review Obstetrics & Gynecology

Uterine natural killer cells: from foe to friend in reproduction

Indra Diaz-Hernandez et al.

Summary: uNK cells play a crucial role in embryo implantation and successful pregnancy. Their functions are closely related to interactions with extravillous trophoblast cells and spiral arteries, regulating vascular function, controlling trophoblast invasion, and promoting placental development. Certain KIR/HLA-C combinations have been associated with recurrent miscarriage, pre-eclampsia, and foetal growth restriction.

HUMAN REPRODUCTION UPDATE (2021)

Review Obstetrics & Gynecology

Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action

Marco Mouanness et al.

Summary: PRP may have potential benefits in improving endometrial thickness and receptivity, but current clinical trial results are conflicting. Further large-scale studies are needed to confirm its effects and identify the patient population that would benefit the most.

REPRODUCTIVE SCIENCES (2021)

Review Immunology

Biology and pathology of the uterine microenvironment and its natural killer cells

Fuyan Wang et al.

Summary: The human uterine mucosa undergoes about 400 monthly cycles of breakdown and regeneration, with immune cells and arterial remodeling playing a crucial role in fetal growth. The transformed arteries in the uterus no longer respond to maternal stimuli, meeting the increasing demands of the growing fetus.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Review Immunology

Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation

Yasuyuki Negishi et al.

Summary: Inflammation plays a crucial role in pregnancy complications, being triggered by both microbial and non-microbial causes. Immune cells and inflammatory mediators are involved in abnormal inflammation, while appropriate inflammation is necessary for successful pregnancy outcomes. Understanding the relationship between pregnancy and inflammation may provide new perspectives on normal pregnancy progress and treatment strategies for pregnancy complications.

IMMUNOLOGICAL MEDICINE (2021)

Article Obstetrics & Gynecology

The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial

Leila Nazari Saghar Salehpour et al.

HUMAN FERTILITY (2020)

Review Physiology

THE FEMALE RESPONSE TO SEMINAL FLUID

John E. Schjenken et al.

PHYSIOLOGICAL REVIEWS (2020)

Review Obstetrics & Gynecology

Recurrent implantation failure in IVF: A Canadian Fertility and Andrology Society Clinical Practice Guideline

Talya Shaulov et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2020)

Article Medicine, General & Internal

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization

Sarah Lensen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Mode of Action of Aspirin in Experimental Autoimmune Encephalomyelitis

Swarupa Pahan et al.

DNA AND CELL BIOLOGY (2019)

Article Pharmacology & Pharmacy

The non-anticoagulant promise of heparin and its mimetics

Barbara Mulloy

CURRENT OPINION IN PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

The role of aspirin and inflammation on reproduction: the EAGeR trial

Lindsay D. Levine et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2019)

Review Obstetrics & Gynecology

The impact of intentional endometrial injury on reproductive outcomes: a systematic review and meta-analysis

Chen Sar-Shalom Nahshon et al.

HUMAN REPRODUCTION UPDATE (2019)

Review Obstetrics & Gynecology

Effect of intrauterine perfusion of human chorionic gonadotropin before embryo transfer after two or more implantation failures: A systematic review and meta-analysis

Hebin Xie et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2019)

Article Obstetrics & Gynecology

Endometrial uNK cell counts do not predict successful implantation in an IVF population

J. F. Donoghue et al.

HUMAN REPRODUCTION (2019)

Article Endocrinology & Metabolism

Administration of prednisolone and low molecular weight heparin in patients with repeated implantation failures: a cohort study

Charalampos Siristatidis et al.

GYNECOLOGICAL ENDOCRINOLOGY (2018)

Article Genetics & Heredity

Should intrauterine human chorionic gonadotropin infusions ever be used prior to embryo transfer?

Michelle Volovsky et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2018)

Article Obstetrics & Gynecology

Acetylsalicylic acid does not prevent first-trimester unexplained recurrent pregnancy loss: A randomized controlled trial

Lennart Blomqvist et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2018)

Review Obstetrics & Gynecology

Implantation failure of endometrial origin: what is new?

Jose Bellver et al.

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY (2018)

Article Immunology

Impact of prednisone in patients with repeated embryo implantation failures: Beneficial or deleterious?

Nathalie Ledee et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2018)

Article Obstetrics & Gynecology

Maternal age and risk for adverse outcomes

Jean-Ju Sheen et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2018)

Article Obstetrics & Gynecology

Innate immune cells in reproduction

Yasuyuki Negishi et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2018)

Review Medicine, Research & Experimental

Regulatory T cells in embryo implantation and the immune response to pregnancy

Sarah A. Robertson et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Obstetrics & Gynecology

Immune modulation treatments-where is the evidence?

Malene Meisner Hviid et al.

FERTILITY AND STERILITY (2017)

Article Obstetrics & Gynecology

Nuclear factor-κB expression in the endometrium of normal and overweight women with polycystic ovary syndrome

Onder Koc et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2017)

Review Immunology

The role of decidual immune cells on human pregnancy

Su Liu et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)

Article Immunology

Uterine immune profiling for increasing live birth rate: A one-to-one matched cohort study

Nathalie Ledee et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)

Article Medicine, General & Internal

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

Daniel L. Rolnik et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Obstetrics & Gynecology

Effects of endometrial injury on frozen-thawed blastocyst transfer in hormone replacement cycles

Yukiko Matsumoto et al.

REPRODUCTIVE MEDICINE AND BIOLOGY (2017)

Review Cell Biology

To serve and to protect: the role of decidual innate immune cells on human pregnancy

Jianhong Zhang et al.

CELL AND TISSUE RESEARCH (2016)

Article Immunology

Multiple immune deviations predictive for IVF failure as possible markers for IVIG therapy

Viktor P. Chernyshov et al.

IMMUNOLOGY LETTERS (2016)

Article Obstetrics & Gynecology

Guillain-Barre Syndrome in Pregnancy

Luis D. Pacheco et al.

OBSTETRICS AND GYNECOLOGY (2016)

Article Developmental Biology

Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial

Ashraf Aleyasin et al.

REPRODUCTION (2016)

Review Immunology

The role of intravenous immunoglobulins in the treatment of rheumatoid arthritis

Nurit Katz-Agranov et al.

AUTOIMMUNITY REVIEWS (2015)

Editorial Material Immunology

Immunosuppression in pregnant women with systemic lupus erythematosus

Claudio Ponticelli et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2015)

Article Obstetrics & Gynecology

First do no harm: uterine natural killer (NK) cells in assisted reproduction

Ashley Moffett et al.

HUMAN REPRODUCTION (2015)

Article Gastroenterology & Hepatology

Intrapartum Corticosteroid use Significantly Increases the Risk of Gestational Diabetes in Women with Inflammatory Bowel Disease

Yvette P. Y. Leung et al.

JOURNAL OF CROHNS & COLITIS (2015)

Article Immunology

Only humans have human placentas: molecular differences between mice and humans

Andre Schmidt et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2015)

Article Immunology

Immune mechanisms at the maternal-fetal interface: perspectives and challenges

Mercy PrabhuDas et al.

NATURE IMMUNOLOGY (2015)

Article Obstetrics & Gynecology

Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study

C. Motteram et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2015)

Review Immunology

The Role of Inflammation for a Successful Implantation

Nava Dekel et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2014)

Article Immunology

Experience in IVIg Therapy for Selected Women with Recurrent Reproductive Failure and NK Cell Expansion

Rocio Ramos-Medina et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2014)

Article Medicine, General & Internal

Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial

Enrique F. Schisterman et al.

LANCET (2014)

Article Biochemistry & Molecular Biology

Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF-β receptor activation

Sarah Berndt et al.

FASEB JOURNAL (2013)

Review Cell Biology

The importance of the macrophage within the human endometrium

Uma Thiruchelvam et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

Article Obstetrics & Gynecology

Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure

Muhammad A. Akhtar et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2013)

Editorial Material Obstetrics & Gynecology

Aspirin and heparin to improve live birth rate in IVF for unexplained implantation failure?

David A. Clark

REPRODUCTIVE BIOMEDICINE ONLINE (2013)

Article Gastroenterology & Hepatology

Neonatal Hemochromatosis

Amy G. Feldman et al.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2013)

Article Immunology

Intravenous Immunoglobulin for Repeated IVF Failure and Unexplained Infertility

Michael R. Virro et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2012)

Letter Allergy

Common variable immune deficiency and treatment with intravenous immunoglobulin during pregnancy

Kimberly A. Brinker et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2012)

Article Obstetrics & Gynecology

Does a single endometrial biopsy regimen (S-EBR) improve ICSI outcome in patients with repeated implantation failure? A randomised controlled trial

Amal Shohayeb et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2012)

Article Obstetrics & Gynecology

The effect of GM-CSF on development and aneuploidy in murine blastocysts

Aisha Elaimi et al.

HUMAN REPRODUCTION (2012)

Review Immunology

Aspirin and immune system

Muzammal Hussain et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2012)

Review Obstetrics & Gynecology

Prednisolone for repeated implantation failure associated with high natural killer cell levels

M. Krigstein et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2012)

Article Immunology

Intralipid therapy for recurrent implantation failure: new hope or false dawn?

N. Shreeve et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2012)

Review Obstetrics & Gynecology

In Vitro Evidences of Heparin's Effects on Embryo Implantation and Trophoblast Development

Chiara Tersigni et al.

REPRODUCTIVE SCIENCES (2012)

Editorial Material Obstetrics & Gynecology

The role of low-molecular-weight heparin in recurrent implantation failure: a prospective, quasi-randomized, controlled study

Bulent Berker et al.

FERTILITY AND STERILITY (2011)

Article Endocrinology & Metabolism

Fetal Adrenal Suppression Due to Maternal Corticosteroid Use: Case Report

Selim Kurtoglu et al.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY (2011)

Article Obstetrics & Gynecology

Low-molecular-weight heparin in women with repeated implantation failure

Corrado Lodigiani et al.

WOMENS HEALTH (2011)

Review Pharmacology & Pharmacy

Safety of intravenous immunoglobulin treatment

James B. Caress et al.

EXPERT OPINION ON DRUG SAFETY (2010)

Article Obstetrics & Gynecology

Local injury of the endometrium induces an inflammatory response that promotes successful implantation

Yulia Gnainsky et al.

FERTILITY AND STERILITY (2010)

Article Obstetrics & Gynecology

Endometrial Decidualization: Of Mice and Men

Cyril Y. Ramathal et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2010)

Article Pathology

Evidence for Immune Cell Involvement in Decidual Spiral Arteriole Remodeling in Early Human Pregnancy

Samantha D. Smith et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

Article Hematology

Heparin, heparan sulfate and heparanase in inflammatory reactions

Jin-ping Li et al.

THROMBOSIS AND HAEMOSTASIS (2009)

Article Pharmacology & Pharmacy

Corticosteroids in patients with antiovarian antibodies undergoing in vitro fertilization:: a prospective pilot study

Thierry Forges et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2006)

Article Immunology

Regulatory T cells mediate maternal tolerance to the fetus

VR Aluvihare et al.

NATURE IMMUNOLOGY (2004)

Article Immunology

Therapy with dendritic cells influences the spontaneous resorption rate in the CBA/J x DBA/2J mouse model

S Blois et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2004)

Article Developmental Biology

Seminal plasma induces mRNA expression of IL-10, IL-6 and LIF in endometrial epithelial cells in vitro

S Gutsche et al.

MOLECULAR HUMAN REPRODUCTION (2003)

Review Biochemistry & Molecular Biology

Reviews: Current Topics - Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (Review)

SA Khan et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2003)